catalog number :
MBS2026220
products full name :
Polyclonal Antibody to Transcobalamin I (TCN1)
products short name :
[Transcobalamin I]
other names :
[transcobalamin-1; Transcobalamin-1; transcobalamin-1; transcobalamin 1; Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI]
products gene name :
[TCN1]
other gene names :
[TCN1; TCN1; HC; TC1; TCI; TC-1; TC1; TC-1; HC; TC I; TCI]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)
app notes :
Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TCN1 (Glu24~Tyr433) expressed in E.coli
ncbi acc num :
NP_001053.2
ncbi gb acc num :
NM_001062.3
ncbi pathways :
Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway (833804); Metabolism Pathway (477135); Metabolism Of Vitamins And Cofactors Pathway (106249); Metabolism Of Water-soluble Vitamins And Cofactors Pathway (106250)
ncbi summary :
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
uniprot summary :
TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11q12.1. Cellular Component: extracellular region; extracellular space. Molecular Function: cobalamin binding. Biological Process: cobalamin metabolic process; cobalamin transport; cobalt ion transport; neutrophil degranulation