Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3) | MyBioSource MBS2026193 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3)

catalog :

MBS2026193

quantity :

0.01 mg

price :

105 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Lane1: Human K562 Cells; Lane2: Human HepG2 Cells.

image 2 :

Western Blot: Sample: Recombinant Flt3, Mouse.

image 3 :

DAB staining on IHC-P; Samples: Mouse Testis Tissue.

product information

catalog number :

MBS2026193

products type :

Antibody

products full name :

Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3)

products short name :

[FMS Like Tyrosine Kinase 3]

other names :

[receptor-type tyrosine-protein kinase FLT3; Receptor-type tyrosine-protein kinase FLT3; receptor-type tyrosine-protein kinase FLT3; FMS-like tyrosine kinase 3; FL cytokine receptor; Fetal liver kinase 2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Tyrosine-protein kinase receptor flk-2; CD_antigen: CD135]

products gene name :

[Flt3]

other gene names :

[Flt3; Flt3; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; Flk-2; Flt-3; FLK-2; FLT-3]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a Rabbit polyclonal antibody raised against Flt3. It has been selected for its ability to recognize Flt3 in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-5µg/mL. Immunohistochemistry: 5-20µg/mL. Immunocytochemistry: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Mouse Kidney Tissue

image5 heading :

Immunohistochemistry (IHC)

image5 description :

DAB staining on IHC-P; Samples: Mouse Skeletal Muscle Tissue.

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant Flt3 (Lys335~Ser544) expressed in E.coli

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2035733

ncbi gi num :

122937353

ncbi acc num :

NP_034359.2

ncbi gb acc num :

NM_010229.2

uniprot acc num :

Q00342

ncbi mol weight :

113,496 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway (83310); Acute Myeloid Leukemia Pathway (529); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83298); Transcriptional Misregulation In Cancer Pathway (523020); Transcriptional Misregulation In Cancer Pathway (522987)

uniprot summary :

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group. Chromosomal Location of Human Ortholog: 5 86.88 cM 5 G3. Cellular Component: cell surface; cytoplasm; cytosol; endoplasmic reticulum; external side of plasma membrane; integral component of membrane; membrane; nucleus; plasma membrane; protein complex. Molecular Function: ATP binding; glucocorticoid receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; kinase activity; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein kinase activity; protein self-association; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; ubiquitin protein ligase binding. Biological Process: antigen processing and presentation; B cell differentiation; cell differentiation; cellular response to cytokine stimulus; cytokine-mediated signaling pathway; hemopoiesis; homeostasis of number of cells within a tissue; leukocyte homeostasis; lymph node development; lymphocyte differentiation; lymphocyte proliferation; lymphoid progenitor cell differentiation; myeloid progenitor cell differentiation; negative regulation of B cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; phosphorylation; positive regulation of interferon-alpha production; positive regulation of interferon-alpha secretion; positive regulation of interferon-gamma production; positive regulation of interferon-gamma secretion; positive regulation of interleukin-12 production; positive regulation of interleukin-12 secretion; positive regulation of multicellular organism growth; positive regulation of protein phosphorylation; post-embryonic development; pro-B cell differentiation; pro-T cell differentiation; protein amino acid phosphorylation; protein autophosphorylation; spleen development; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

170

size4 :

0.1 mg

price4 :

210

size5 :

0.2 mg

price5 :

315

size6 :

1 mg

price6 :

745

more info or order :

MyBioSource product webpage