Polyclonal Antibody to Filamin C Gamma (FLNC) | MyBioSource MBS2026155 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Filamin C Gamma (FLNC)

catalog :

MBS2026155

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Figure. Western Blot; Sample: Recombinant FLNC, Human.

image 2 :

DAB staining on IHC-P; Samples: Human Prostate cancer Tissue;. Primary Ab: 10ug/ml Rabbit Anti-Human FLNC Antibody. Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody. (Catalog: MBS2086047 )

image 3 :

DAB staining on IHC-P; Samples: Human Breast cancer Tissue;. Primary Ab: 10ug/ml Rabbit Anti- Human FLNC Antibody. Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody. (Catalog: MBS2086047 )

product information

catalog number :

MBS2026155

products type :

Antibody

products full name :

Polyclonal Antibody to Filamin C Gamma (FLNC)

products short name :

[Filamin C Gamma]

other names :

[filamin-C isoform b; Filamin-C; filamin-C; filamin C; ABP-280-like protein; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin]

products gene name :

[FLNC]

other gene names :

[FLNC; FLNC; ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A; ABPL; FLN2; FLN-C; FLNc]

clonality :

polyclonal

host :

rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.25mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

app notes :

Western blotting: 0.5-2ug/mL;. Immunohistochemistry: 5-20ug/mL;. Immunocytochemistry: 5-20ug/mL;. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant FLNC (Glu17~Lys259 (Accession # Q14315)) expressed in E.coli ( MBS2030652 )

ncbi gi num :

188595687

ncbi acc num :

NP_001120959.1

ncbi gb acc num :

NM_001127487.1

uniprot acc num :

Q14315

ncbi pathways :

Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-extracellular Matrix Interactions Pathway (1270237); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054); Salmonella Infection Pathway (375172)

ncbi summary :

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

FLNC: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Defects in FLNC are the cause of myopathy myofibrillar type 5 (MFM5). A neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations, and clinical features of a limb-girdle myopathy. Defects in FLNC are the cause of myopathy distal type 4 (MPD4). MPD4 is a slowly progressive muscular disorder characterized by distal muscle weakness and atrophy affecting the upper and lower limbs. Onset occurs around the third to fourth decades of life, and patients remain ambulatory even after long disease duration. Muscle biopsy shows non-specific changes with no evidence of rods, necrosis, or inflammation. Belongs to the filamin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 7q32.1. Cellular Component: costamere; cytoplasm; cytoskeleton; cytosol; focal adhesion; plasma membrane; sarcolemma; sarcoplasm; Z disc. Molecular Function: actin filament binding; ankyrin binding; cytoskeletal protein binding; protein binding. Biological Process: muscle fiber development. Disease: Cardiomyopathy, Familial Hypertrophic, 26; Myopathy, Distal, 4; Myopathy, Myofibrillar, 5

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

340

size6 :

1 mg

price6 :

800

more info or order :

MyBioSource product webpage