Polyclonal Antibody to Tomoregulin (TR) | MyBioSource MBS2026100 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Tomoregulin (TR)

catalog :

MBS2026100

quantity :

0.01 mg

price :

115 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant Tomoregulin, Human.

image 2 :

DAB staining on fromalin fixed paraffin- embedded Kidney tissue)

product information

catalog number :

MBS2026100

products type :

Antibody

products full name :

Polyclonal Antibody to Tomoregulin (TR)

products short name :

[Tomoregulin]

other names :

[tomoregulin-2 isoform 2; Tomoregulin-2; tomoregulin-2; transmembrane protein with EGF like and two follistatin like domains 2; Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains]

products gene name :

[TR]

other gene names :

[TMEFF2; TMEFF2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2; HPP1; TENB2; TPEF; TR-2]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

The antibody is a Rabbit polyclonal antibody raised against TR. It has been selected for its ability to recognize TR in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant tomoregulin (Thr52~Arg290) expressed in E.coli.

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2083845

ncbi gi num :

762205498

ncbi acc num :

NP_001292063.1

ncbi gb acc num :

NM_001305134.1

uniprot acc num :

Q9UIK5

ncbi mol weight :

19,472 Da

ncbi pathways :

Validated Targets Of C-MYC Transcriptional Repression Pathway (169353)

ncbi summary :

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

uniprot summary :

TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB. Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q32.3. Cellular Component: extracellular region; integral component of membrane. Biological Process: negative regulation of cell migration; negative regulation of integrin biosynthetic process; negative regulation of stress fiber formation

size1 :

0.01 mg

price1 :

115 USD

size2 :

0.02 mg

price2 :

135

size3 :

0.05 mg

price3 :

190

size4 :

0.1 mg

price4 :

245

size5 :

0.2 mg

price5 :

370

size6 :

1 mg

price6 :

875

more info or order :

MyBioSource product webpage