Polyclonal Antibody to Activin A (ACVA) | MyBioSource MBS2025980 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Activin A (ACVA)

catalog :

MBS2025980

quantity :

0.01 mg

price :

90 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant ACVA, Human.

image 2 :

DAB staining on fromalin fixed paraffin- embedded Kidney tissue)

product information

catalog number :

MBS2025980

products type :

Antibody

products full name :

Polyclonal Antibody to Activin A (ACVA)

products short name :

[Activin A]

other names :

[inhibin beta A chain preproprotein; Inhibin beta A chain; inhibin beta A chain; inhibin beta A subunit; Activin beta-A chain; Erythroid differentiation protein; EDF]

products gene name :

[ACVA]

other gene names :

[INHBA; INHBA; EDF; FRP; EDF]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.92 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2(Ug/mL;1:450-1800 . Immunohistochemistry: 5-20(Ug/mL;1:45-180. Immunocytochemistry: 5-20(Ug/mL;1:45-180. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant ACVA (Pro44~Gln178) expressed in E.coli

ncbi gi num :

4504699

ncbi acc num :

NP_002183.1

ncbi gb acc num :

NM_002192.3

uniprot acc num :

P08476

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Antagonism Of Activin By Follistatin Pathway (730350); Cardiac Progenitor Differentiation Pathway (712094); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Glycoprotein Hormones Pathway (160989); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Peptide Hormone Biosynthesis Pathway (160988); Peptide Hormone Metabolism Pathway (771603)

ncbi summary :

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

uniprot summary :

INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7p14.1. Cellular Component: extracellular region; perinuclear region of cytoplasm. Molecular Function: cytokine activity; growth factor activity; hormone activity; identical protein binding; peptide hormone binding; protein binding; protein heterodimerization activity; transforming growth factor beta receptor binding. Biological Process: activin receptor signaling pathway; cell cycle arrest; cell development; cell differentiation; cell surface receptor signaling pathway; cell-cell signaling; defense response; erythrocyte differentiation; G1/S transition of mitotic cell cycle; hair follicle development; hemoglobin biosynthetic process; hemopoietic progenitor cell differentiation; male gonad development; mesodermal cell differentiation; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of follicle-stimulating hormone secretion; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; nervous system development; odontogenesis; ovarian follicle development; palate development; positive regulation of cellular protein metabolic process; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; progesterone secretion; regulation of follicle-stimulating hormone secretion; regulation of MAPK cascade; regulation of transcription from RNA polymerase II promoter; response to drug; striatal medium spiny neuron differentiation

size1 :

0.01 mg

price1 :

90 USD

size2 :

0.02 mg

price2 :

105

size3 :

0.05 mg

price3 :

135

size4 :

0.1 mg

price4 :

165

size5 :

0.2 mg

price5 :

230

size6 :

1 mg

price6 :

515

more info or order :

MyBioSource product webpage