Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP) | MyBioSource MBS2025901 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)

catalog :

MBS2025901

quantity :

0.01 mg

price :

105 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant NT-ProANP, Human.

image 2 :

DAB staining on IHC-P; Samples: Human Prostate Gland Tissue

image 3 :

DAB staining on IHC-P; Samples: Human Stomach Tissue.

product information

catalog number :

MBS2025901

products type :

Antibody

products full name :

Polyclonal Antibody to N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP)

products short name :

[N-Terminal Pro-Atrial]

other names :

[natriuretic peptides A preproprotein; Natriuretic peptides A; natriuretic peptides A; natriuretic peptide A; CDD-ANF; Cardiodilatin; CDD]

products gene name :

[NT-ProANP]

other gene names :

[NPPA; NPPA; ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF; ANP; PND; CDD; CDP; ANF; ANP]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

The antibody is a Rabbit polyclonal antibody raised against NT-ProANP. It has been selected for its ability to recognize NT-ProANP in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200µg/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-2µg/mL. Immunohistochemistry: 5-20µg/mL. Immunocytochemistry: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue.

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant NT-ProANP (Ala25~Arg123) expressed in E.coli.

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2042969

ncbi gi num :

23510319

ncbi acc num :

NP_006163.1

ncbi gb acc num :

NM_006172.3

uniprot acc num :

P01160

ncbi mol weight :

16,708 Da

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1 Signaling Pathway (695200); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway (576276)

ncbi summary :

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]

uniprot summary :

NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family. Protein type: Hormone; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: extracellular matrix; extracellular region; extracellular space; mast cell granule; nucleus; perinuclear region of cytoplasm; protein complex. Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; protein binding; receptor binding. Biological Process: cardiac muscle hypertrophy in response to stress; cellular protein metabolic process; cGMP biosynthetic process; female pregnancy; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; neuropeptide signaling pathway; positive regulation of heart rate; protein folding; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel size; response to hypoxia; response to insulin stimulus; transcription initiation from RNA polymerase II promoter. Disease: Atrial Fibrillation, Familial, 6; Atrial Standstill 2

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

165

size4 :

0.1 mg

price4 :

210

size5 :

0.2 mg

price5 :

310

size6 :

1 mg

price6 :

725

more info or order :

MyBioSource product webpage