Monoclonal Antibody to Epstein Barr Virus Induced Protein 3 (EBI3) | MyBioSource MBS2025738 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal Antibody to Epstein Barr Virus Induced Protein 3 (EBI3)

catalog :

MBS2025738

quantity :

0.01 mg

price :

105 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2-3#]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant EBI3, Human.

image 2 :

DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue

image 3 :

DAB staining on IHC-P; Samples: Human Breast Cancer Tissue.

product information

catalog number :

MBS2025738

products type :

Antibody

products full name :

Monoclonal Antibody to Epstein Barr Virus Induced Protein 3 (EBI3)

products short name :

[Epstein Barr Virus Induced Protein 3]

other names :

[interleukin-27 subunit beta; Interleukin-27 subunit beta; interleukin-27 subunit beta; Epstein-Barr virus induced 3; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein]

products gene name :

[EBI3]

other gene names :

[EBI3; EBI3; IL27B; IL35B; IL-27B; IL27B; IL-27 subunit beta; IL-27B; EBV-induced gene 3 protein]

clonality :

Monoclonal

isotype :

IgG1 Kappa

clone :

[2-3#]

host :

Mouse

purity :

Protein A + Protein G affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

1 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Human Stomach Tissue.

image5 heading :

Immunohistochemistry (IHC)

image5 description :

DAB staining on IHC-P; Samples: Human Kidney Tissue.

other info1 :

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant EBI3 (Arg21~Lys229) expressed in E.coli

ncbi gi num :

14577917

ncbi acc num :

NP_005746.2

ncbi gb acc num :

NM_005755.2

uniprot acc num :

Q14213

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); IL-6-type Cytokine Receptor Ligand Interactions Pathway (1339143); IL27-mediated Signaling Events Pathway (137929); Immune System Pathway (1269170); Interleukin-6 Family Signaling Pathway (1339142); Signaling By Interleukins Pathway (1269318)

ncbi summary :

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

uniprot summary :

IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane. Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein binding. Biological Process: humoral immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of interferon-gamma biosynthetic process; T cell proliferation; T-helper 1 type immune response

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

110

size3 :

0.05 mg

price3 :

145

size4 :

0.1 mg

price4 :

185

size5 :

0.2 mg

price5 :

235

size6 :

1 mg

price6 :

540

more info or order :

MyBioSource product webpage