Jagged 1 Protein (JAG1) ELISA Kit | MyBioSource MBS2020697 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Jagged 1 Protein (JAG1) ELISA Kit

catalog :

MBS2020697

quantity :

24-Strip-Wells

price :

260 USD

product information

catalog number :

MBS2020697

products type :

ELISA Kit

products full name :

Jagged 1 Protein (JAG1) ELISA Kit

products short name :

[Jagged 1 Protein (JAG1)]

products name syn :

[CD339; AGS; AHD; AWS; HJ1; JAGL1; Alagille Syndrome]

other names :

[jagged 1, partial; Jagged 1; protein jagged-1; jagged 1; Jagged 1]

products gene name :

[JAG1]

other gene names :

[JAG1; JAG1; AGS; AHD; AWS; HJ1; CD339; JAGL1]

uniprot entry name :

B7U6M9_HUMAN

reactivity :

Human

sequence length :

specificity :

This assay has high sensitivity and excellent specificity for detection of JAG1. No significant cross-reactivity or interference between JAG1 and analogues was observed.

storage stability :

The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: human serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. Detection Range: 0.156-10ng/mL. Sensitivity: <0.059ng/mL

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level JAG1 were tested 20 times on one plate, respectively. Intra-Assay: CV<10%. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level JAG1 were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100. Inter-Assay: CV<12%

products categories :

Signal transduction; CD & Adhesion molecule; Tumor immunity; Hematology

products description :

Intended Uses: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of JAG1 in human serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

ncbi gi num :

215536139

ncbi acc num :

ACJ68517.1

ncbi mol weight :

4,286 Da

ncbi pathways :

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (1269536); Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway (1268887); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (1268891); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (1268889); Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway (1268885); Delta-Notch Signaling Pathway (198879); Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855); NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway (1269539); Notch Signaling Pathway (198891)

ncbi summary :

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

uniprot summary :

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 20p12.1-p11.23. Cellular Component: membrane; integral to plasma membrane; apical part of cell; extracellular region; plasma membrane. Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activity. Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; myoblast differentiation; keratinocyte differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway. Disease: Tetralogy Of Fallot; Alagille Syndrome 1

size1 :

24-Strip-Wells

price1 :

260 USD

size2 :

48-Strip-Wells

price2 :

475

size3 :

96-Strip-Wells

price3 :

640

size4 :

5x96-Strip-Wells

price4 :

2590

size5 :

10x96-Strip-Wells

price5 :

4670