Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) | MyBioSource MBS2018550 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB)

catalog :

MBS2018550

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2018550

products type :

Recombinant Protein

products full name :

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB)

products short name :

[Protein Tyrosine Phosphatase Receptor Type B (PTPRB)]

other names :

[receptor-type tyrosine-protein phosphatase beta isoform a; Receptor-type tyrosine-protein phosphatase beta; receptor-type tyrosine-protein phosphatase beta; VE-PTP; vascular endothelial protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, beta polypeptide; protein tyrosine phosphatase, receptor type, B; Vascular endothelial protein tyrosine phosphatase]

products gene name :

[PTPRB]

other gene names :

[PTPRB; PTPRB; PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA; PTPB; Protein-tyrosine phosphatase beta; R-PTP-beta; VE-PTP]

uniprot entry name :

PTPRB_HUMAN

host :

E Coli

purity :

> 97%

concentration :

Original Concentration: 200 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS%PAGE; WB. (May be suitable for use in other assays to be determined by the end user.

image1 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Ala1655~Asp1918. Tags: N-terminal His Tag. Traits: Freeze & dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.

other info2 :

Predicted isoelectric point: 7.3. Predicted Molecular Mass: 34.1kDa. Accurate Molecular Mass: 32kDa as determined by SDS%PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1%1.0 mg/mL. Do not vortex.

ncbi gi num :

157952215

ncbi acc num :

NP_001103224.1

ncbi gb acc num :

NM_001109754.2

uniprot acc num :

P23467

ncbi pathways :

Adherens Junction Pathway (83070); Adherens Junction Pathway (481)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

uniprot summary :

PTPRB: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine. Chromosomal Location of Human Ortholog: 12q15-q21. Cellular Component: integral to plasma membrane; receptor complex. Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity. Biological Process: dephosphorylation; angiogenesis; protein amino acid dephosphorylation; phosphate metabolic process

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

270

size3 :

0.1 mg

price3 :

420

size4 :

0.2 mg

price4 :

515

size5 :

0.5 mg

price5 :

995

size6 :

1 mg

price6 :

1480

more info or order :

MyBioSource product webpage