Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1) | MyBioSource MBS2018424 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)

catalog :

MBS2018424

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2018424

products type :

Recombinant Protein

products full name :

Recombinant LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)

products short name :

[LIM And Senescent Cell Antigen Like Domains Protein 1 (LIMS1)]

other names :

[LIM and senescent cell antigen-like-containing domain protein 1 isoform c; LIM and senescent cell antigen-like-containing domain protein 1; LIM and senescent cell antigen-like-containing domain protein 1; renal carcinoma antigen NY-REN-48; particularly interesting new Cys-His protein 1; LIM and senescent cell antigen-like domains 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48]

products gene name :

[LIMS1]

other gene names :

[LIMS1; LIMS1; PINCH; PINCH1; PINCH-1; PINCH; PINCH1; PINCH-1]

uniprot entry name :

LIMS1_HUMAN

host :

E.coli

purity :

> 90%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose

concentration :

Original Concentration: 200 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB)

app notes :

(May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence

image2 heading :

SDS-PAGE

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Ala68~Cys303. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 8.6. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

301601605

ncbi acc num :

NP_001180411.1

ncbi gb acc num :

NM_001193482.1

uniprot acc num :

P48059

ncbi mol weight :

Predicted Molecular Mass: 30.5kDa. Accurate Molecular Mass: 28kDa as determined by SDS-PAGE reducing conditions

ncbi pathways :

Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-extracellular Matrix Interactions Pathway (160967); Regulation Of Cytoskeletal Remodeling And Cell Spreading By IPP Complex Components Pathway (160969)

ncbi summary :

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

uniprot summary :

LIMS1: Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 2q12.3. Cellular Component: protein complex; focal adhesion; perinuclear region of cytoplasm; plasma membrane; intercellular junction; cytosol. Molecular Function: protein binding; zinc ion binding; protein kinase binding. Biological Process: intercellular junction assembly and maintenance; chordate embryonic development; protein heterooligomerization; cell-matrix adhesion; establishment and/or maintenance of cell polarity; cell aging; regulation of epithelial cell proliferation; cell-cell adhesion; establishment of protein localization; positive regulation of focal adhesion formation; epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent; positive regulation of GTPase activity; negative regulation of apoptosis

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

270

size3 :

0.1 mg

price3 :

425

size4 :

0.2 mg

price4 :

520

size5 :

0.5 mg

price5 :

1005

size6 :

1 mg

price6 :

1500

more info or order :

MyBioSource product webpage