protein

Recombinant Janus Kinase 1 (JAK1)

MBS2018398

0.01 mg

145 USD

Recombinant Protein

Recombinant Janus Kinase 1 (JAK1)

[Janus Kinase 1 (JAK1)]

[Tyrosine-protein kinase JAK1; Tyrosine-protein kinase JAK1; tyrosine-protein kinase JAK1; JAK-1; Janus kinase 1; Janus kinase 1]

[JAK1]

[Jak1; Jak1; AA960307; C130039L05Rik; JAK-1]

JAK1_MOUSE

E. coli

Mouse

>98%

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Source: Prokaryotic expression. Residues: Gln833~Leu1074. Tags: N-terminal His-Tag. Subcellular Location: Endomembrane system; Peripheral membrane protein. Traits: Freeze-dried powder. Predicted isoelectric point: 6.9. Predicted Molecular Mass: 31.7kDa. Accurate Molecular Mass: 32kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

1708580

P52332.1

P52332

Antiviral Mechanism By IFN-stimulated Genes Pathway (926151); Cytokine Signaling In Immune System Pathway (926145); EGFR1 Signaling Pathway (198278); ESC Pluripotency Pathways (198374); Epstein-Barr Virus Infection Pathway (585576); Epstein-Barr Virus Infection Pathway (587115); HTLV-I Infection Pathway (373903); HTLV-I Infection Pathway (373889); Hepatitis B Pathway (694729); Hepatitis C Pathway (173974)

JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.2; TK group; JakA family. Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; focal adhesion; membrane; cytoplasm; intracellular; nucleus. Molecular Function: transferase activity; protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; protein phosphatase binding; ATP binding; protein kinase activity; CCR5 chemokine receptor binding. Biological Process: response to antibiotic; cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; phosphorylation; enzyme linked receptor protein signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation

0.01 mg

145 USD

0.05 mg

285

0.1 mg

445

0.2 mg

545

0.5 mg

1055

1 mg

1575