FITC-linked Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) | MyBioSource MBS2018121 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)

catalog :

MBS2018121

quantity :

0.1 mg

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2018121

products type :

Antibody

products full name :

FITC-linked Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)

products short name :

[Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)]

other names :

[leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18]

products gene name :

[LILRB4]

other gene names :

[LILRB4; LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; ILT3; LIR5; ILT-3; LIR-5]

uniprot entry name :

LIRB4_HUMAN

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 1%BSA ,0.05% Proclin-300, 50% glycerol.

concentration :

0.5mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

Western blotting: 0.5-2ug/mL;1:250-1000. Immunohistochemistry: 5-20ug/mL;1:25-100. Immunocytochemistry: 5-20ug/mL;1:25-100. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Mus musculus(Mouse). Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant LILRB4 (Gly24~Val206) expressed in E.coli.

products categories :

FITC Antibody

ncbi gi num :

510025457

ncbi acc num :

NP_001265358.1

ncbi gb acc num :

NM_001278429.2

uniprot acc num :

Q8NHJ6

ncbi pathways :

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; receptor activity; antigen binding. Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.2 mg

price2 :

390

size3 :

1 mg

price3 :

935

more info or order :

MyBioSource product webpage