antibody

FITC-linked Antibody to Ficolin 1 (FCN1)

MBS2017851

0.1 mg

245 USD

polyclonal

rabbit

FITC

western blot, immunohistochemistry, immunocytochemistry

Antibody

FITC-linked Antibody to Ficolin 1 (FCN1)

[Ficolin 1 (FCN1)]

[ficolin-1; Ficolin-1; ficolin-1; M-ficolin; ficolin-A; ficolin-alpha; collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1; ficolin (collagen/fibrinogen domain containing) 1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin]

[FCN1]

[FCN1; FCN1; FCNM; FCNM]

FCN1_HUMAN

Polyclonal

Rabbit

Antigen-specific Affinity Chromatography

Supplied as solution form in PBS, pH 7.4 containing 1%BSA, 0.02% NaN3, 50% glycerol.

0.31 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20oC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF).

Western blotting: 0.5-2 ug/mL;1:150-620. Immunohistochemistry: 5-20 ug/mL;1:150-620. Immunocytochemistry: 5-20 ug/mL;1:150-620. Optimal working dilutions must be determined by end user

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant FCN1 (Asp45~Thr249) expressed in E.coli.

FITC Antibody

8051584

NP_001994.2

NM_002003.3

O00602

Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway (833818); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Lectin Pathway Of Complement Activation (106408)

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

FCN1: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Belongs to the ficolin lectin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region. Molecular Function: protein binding; G-protein-coupled receptor binding; metal ion binding; carbohydrate binding; pattern recognition receptor activity; sialic acid binding. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; complement activation

0.1 mg

245 USD

0.2 mg

365

1 mg

865