FITC-linked Antibody to Transcription Factor A, Mitochondrial (TFAM) | MyBioSource MBS2016970 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Transcription Factor A, Mitochondrial (TFAM)

catalog :

MBS2016970

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2016970

products type :

Antibody

products full name :

FITC-linked Antibody to Transcription Factor A, Mitochondrial (TFAM)

products short name :

[Transcription Factor A, Mitochondrial (TFAM)]

other names :

[transcription factor A, mitochondrial isoform 1; Transcription factor A, mitochondrial; transcription factor A, mitochondrial; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor A, mitochondrial; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2]

products gene name :

[TFAM]

other gene names :

[TFAM; TFAM; TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; TCF6; TCF6L2; mtTFA; MtTF1; TCF-6]

uniprot entry name :

TFAM_HUMAN

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.38 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

WB; IHC; ICC; IF.

app notes :

Western blotting: 0.5-2 Ug/mL;1:200-800. Immunohistochemistry: 5-20 Ug/mL;1:20-80. Immunocytochemistry. 5-20, Ug/mL;1:20-80. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Mus musculus (Mouse). Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant TFAM (Ser43~His243) expressed in E.coli.

products categories :

FITC Antibody

ncbi gi num :

4507401

ncbi acc num :

NP_003192.1

ncbi gb acc num :

NM_003201.2

uniprot acc num :

Q00059

ncbi pathways :

Energy Metabolism Pathway (198907); Gene Expression Pathway (105937); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Mitochondrial Gene Expression Pathway (198757); Mitochondrial Transcription Initiation Pathway (106569); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); Transcription From Mitochondrial Promoters Pathway (106568)

ncbi summary :

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

uniprot summary :

TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Protein type: Transcription regulation; DNA-binding. Chromosomal Location of Human Ortholog: 10q21. Cellular Component: mitochondrion; mitochondrial matrix; nucleus; cytosol. Molecular Function: protein binding; heat shock protein binding; chromatin binding; transcription factor activity; DNA bending activity. Biological Process: mitochondrial respiratory chain complex assembly; chromatin remodeling; mitochondrion organization and biogenesis; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter

size1 :

0.1 mg

price1 :

265 USD

size2 :

0.2 mg

price2 :

410

size3 :

1 mg

price3 :

985

more info or order :

MyBioSource product webpage