FITC-linked Antibody to Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8) | MyBioSource MBS2016691 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8)

catalog :

MBS2016691

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2016691

products type :

Antibody

products full name :

FITC-linked Antibody to Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8)

products short name :

[Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8)]

other names :

[myosin-8; Myosin-8; myosin-8; myHC-perinatal; myosin heavy chain 8; fetal-myosin heavy chain; myosin heavy chain, skeletal muscle, perinatal; myosin, heavy polypeptide 8, skeletal muscle, perinatal; myosin, heavy chain 8, skeletal muscle, perinatal; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal]

products gene name :

[MYH8]

other gene names :

[MYH8; MYH8; MyHC-pn; gtMHC-F; MyHC-peri; MyHC-perinatal]

uniprot entry name :

MYH8_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Rat

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as a solution form in 0.01M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage conditions. Note: Fluorescence can be photobleached when exposed to light, so the antibody must be protected from light.

tested application :

WB; IHC; ICC; IP

app notes :

Western Blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by the end user.

other info1 :

Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant MYH8 (His40~Val240) expressed in E.coli

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2007193

products categories :

FITC Antibody

ncbi gi num :

153945790

ncbi acc num :

NP_002463.2

ncbi gb acc num :

NM_002472.2

uniprot acc num :

P13535

ncbi pathways :

Membrane Trafficking Pathway (106160); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262); Tight Junction Pathway (83071); Tight Junction Pathway (482); Translocation Of GLUT4 To The Plasma Membrane Pathway (685554)

ncbi summary :

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]

uniprot summary :

MYH8: Muscle contraction. Defects in MYH8 are a cause of Carney complex variant (CACOV). Carney complex is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Familial cardiac myxomas are associated with spotty pigmentation of the skin and other phenotypes, including primary pigmented nodular adrenocortical dysplasia, extracardiac (frequently cutaneous) myxomas, schwannomas, and pituitary, thyroid, testicular, bone, ovarian, and breast tumors. Cardiac myxomas do not develop in all patients with the Carney complex, but affected patients have at least two features of the complex or one feature and a clinically significant family history. Defects in MYH8 are a cause of distal arthrogryposis type (DA7). A hereditary distal arthrogryposis characterized by an inability to open the mouth fully (trismus) and pseudocamptodactyly in which wrist dorsiflexion, but not volarflexion, produces involuntary flexion contracture of distal and proximal interphalangeal joints. Such hand and jaw contractures are caused by shortened flexor muscle-tendon units. Similar lower-limb contractures also produce foot deformity. The trismus-pseudocamptodactyly syndrome is a morbid autosomal dominant trait with variable expressivity but high penetrance. In these patients, trismus complicates dental care, feeding during infancy, and intubation for anesthesia, and the pseudocamptodactyly impairs manual dexterity, with consequent occupational and social disability. Many patients require surgical correction of contractures. Protein type: Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: sarcomere; cytoplasm; muscle myosin complex; cytosol. Molecular Function: calmodulin binding; actin filament binding; microfilament motor activity; structural constituent of muscle; ATPase activity; myosin light chain binding; ATP binding. Biological Process: skeletal muscle contraction; muscle contraction; metabolic process; muscle filament sliding. Disease: Carney Complex Variant; Arthrogryposis, Distal, Type 7

size1 :

0.1 mg

price1 :

280 USD

size2 :

0.2 mg

price2 :

435

size3 :

1 mg

price3 :

1030

more info or order :

MyBioSource product webpage