catalog number :
MBS2015181
products full name :
Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)
products short name :
[Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)]
other names :
[cytotoxic T-lymphocyte protein 4 isoform 1; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152]
products gene name :
[CTLA4]
other gene names :
[Ctla4; Ctla4; Cd152; Ly-56; Ctla-4; Cd152; CTLA-4]
specificity :
The antibody is a Rabbit polyclonal antibody raised against CTLA4. It has been selected for its ability to recognize CTLA4 in immunohistochemical staining and western blotting.
purity :
Antigen-specific Affinity Chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for two years. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP
app notes :
Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant CTLA4 (Val45~Ser185) expressed in E.coli
other info2 :
Source: Polyclonal antibody preparation. Traits: Liquid. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2052853
ncbi acc num :
NP_033973.2
ncbi gb acc num :
NM_009843.4
ncbi mol weight :
24,993 Da
ncbi pathways :
Adaptive Immune System Pathway (1367473); Autoimmune Thyroid Disease Pathway (83314); Autoimmune Thyroid Disease Pathway (533); CTLA4 Inhibitory Signaling Pathway (1367483); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (1367479); Immune System Pathway (1367472); Rheumatoid Arthritis Pathway (200310); Rheumatoid Arthritis Pathway (200269)
ncbi summary :
This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
uniprot summary :
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.