product summary
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company name :
MyBioSource
product type :
antibody
product name :
FITC-linked Antibody to Jagged 2 Protein (JAG2)
catalog :
MBS2015132
quantity :
0.1 mg
price :
460 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2015132
products type :
Antibody
products full name :
FITC-linked Antibody to Jagged 2 Protein (JAG2)
products short name :
Jagged 2 Protein (JAG2)
other names :
jagged 2 isoform b variant; Protein jagged-2; protein jagged-2; jagged 2
products gene name :
JAG2
other gene names :
JAG2; JAG2; HJ2; SER2; Jagged2; hJ2
uniprot entry name :
JAG2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
sequence length :
180
sequence :
The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-FQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL PRSGHLDNNC ARLTLHFNRD H
specificity :
The antibody is a rabbit polyclonal antibody raised against JAG2. It has been selected for its ability to recognize JAG2 in immunohistochemical staining and western blotting.
purity :
Affinity Chromatography
concentration :
180 ug/mL
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
tested application :
Western blotting (WB). Immunocytochemistry (ICC). Immunohistochemistry (IHC-F). Immunohistochemistry (IHC-P). Enzyme-linked Immunosorbent Assay (ELISA). Optimal working dilutions must be determined by end user.
app notes :
Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.
products categories :
FITC Antibody
ncbi gi num :
62088320
ncbi acc num :
BAD92607.1
uniprot acc num :
Q9Y219
ncbi mol weight :
133,367 Da
ncbi pathways :
Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway (771591); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway (771589); Delta-Notch Signaling Pathway (198879); Disease Pathway (530764); FBXW7 Mutants And NOTCH1 In Cancer Pathway (771596); NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway (771602); Notch Signaling Pathway (198891)
ncbi summary :
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 14q32. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding. Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; auditory receptor cell fate commitment; cell differentiation; skeletal development; gamma-delta T cell differentiation; T cell differentiation
size1 :
0.1 mg
price1 :
460 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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