FITC-linked Antibody to Glutamine synthetase (GS) | MyBioSource MBS2014862 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Glutamine synthetase (GS)

catalog :

MBS2014862

quantity :

0.1 mg

price :

260 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2014862

products type :

Antibody

products full name :

FITC-linked Antibody to Glutamine synthetase (GS)

products short name :

[Glutamine synthetase (GS)]

other names :

[glutamine synthetase; Glutamine synthetase; glutamine synthetase; glutamine synthase; glutamate decarboxylase; glutamate--ammonia ligase; proliferation-inducing protein 43; cell proliferation-inducing protein 59; glutamate-ammonia ligase; Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase]

products gene name :

[GS]

other gene names :

[GLUL; GLUL; GS; GLNS; PIG43; PIG59; GLNS; GS]

uniprot entry name :

GLNA_HUMAN

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol

concentration :

0.34 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

WB; IHC; ICC; IF.

app notes :

Western blotting: 0.5-2- Ug/mL;1:170-650. Immunohistochemistry: 5-20-Ug/mL;1:17-65. Immunocytochemistry: 5-20-Ug/mL;1:17-65. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Homo sapiens (Human. Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant GS (Met1~Asn373) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2005100

products categories :

FITC Antibody

ncbi gi num :

74271837

ncbi acc num :

NP_001028216.1

ncbi gb acc num :

NM_001033044.2

uniprot acc num :

P15104

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway (106533); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129)

ncbi summary :

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family. Protein type: EC 4.1.1.15; Energy Metabolism - nitrogen; Amino Acid Metabolism - arginine and proline; EC 6.3.1.2; Amino Acid Metabolism - alanine, aspartate and glutamate; Ligase. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: protein complex; mitochondrion; rough endoplasmic reticulum; cytoplasm; perikaryon; nerve terminal; nucleus; cytosol. Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding. Biological Process: glutamate catabolic process; cell proliferation; synaptic transmission; glutamine biosynthetic process; response to glucose stimulus; neurotransmitter uptake; positive regulation of insulin secretion; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization. Disease: Glutamine Deficiency, Congenital

size1 :

0.1 mg

price1 :

260 USD

size2 :

0.2 mg

price2 :

400

size3 :

1 mg

price3 :

955

more info or order :

MyBioSource product webpage