catalog number :
MBS2014690
products full name :
FITC-linked Antibody to Protein Tyrosine Phosphatase Receptor Type S (PTPRS)
products short name :
[Protein Tyrosine Phosphatase Receptor Type S (PTPRS)]
other names :
[protein tyrosine phosphatase, receptor type, S, isoform CRA_h; Receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; protein tyrosine phosphatase, receptor type, sigma; protein tyrosine phosphatase, receptor type, S; Receptor-type tyrosine-protein phosphatase sigma]
products gene name :
[PTPRS]
other gene names :
[PTPRS; PTPRS; PTPSIGMA; R-PTP-S; R-PTP-sigma]
uniprot entry name :
PTPRS_HUMAN
purity :
Antigen-specific Affinity Chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
tested application :
WB; IHC; ICC; IF
app notes :
Western blotting: 0.5-2µg/mL. Immunohistochemistry: 5-20µg/mL. Immunocytochemistry: 5-20µg/mL. Optimal working dilutions must be determined by end user
other info1 :
Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant PTPRS (Arg889~His1102) expressed in E.coli
products categories :
FITC Antibody
ncbi acc num :
EAW69178.1
ncbi pathways :
ECM Proteoglycans Pathway (833812); Extracellular Matrix Organization Pathway (576262)
ncbi summary :
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
uniprot summary :
PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: integral to plasma membrane. Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity. Biological Process: corpus callosum development; extracellular matrix organization and biogenesis; spinal cord development; hippocampus development; cerebellum development; cerebral cortex development; cell adhesion