FITC-linked Antibody to Phospholipase A2 Receptor 1 (PLA2R1) | MyBioSource MBS2014684 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Phospholipase A2 Receptor 1 (PLA2R1)

catalog :

MBS2014684

quantity :

0.1 mg

price :

260 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2014684

products type :

Antibody

products full name :

FITC-linked Antibody to Phospholipase A2 Receptor 1 (PLA2R1)

products short name :

[Phospholipase A2 Receptor 1 (PLA2R1)]

other names :

[phospholipase A2 receptor 1, 180kDa, isoform CRA_b; Secretory phospholipase A2 receptor; secretory phospholipase A2 receptor; M-type receptor; C-type lectin domain family 13 member C; 180 kDa secretory phospholipase A2 receptor; phospholipase A2 receptor 1, 180kDa; 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor]

products gene name :

[PLA2R1]

other gene names :

[PLA2R1; PLA2R1; PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R; CLEC13C; PLA2-R; PLA2R; Soluble PLA2-R]

uniprot entry name :

PLA2R_HUMAN

clonality :

polyclonal

host :

rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in PBS pH 7.4 1% BSA 50% glycerol 0.05% Proclin-300.

concentration :

0.36 mg/ml

storage stability :

Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunofluorescence (IF).

app notes :

Western blotting: 0.5-2 ug/mL;. Immunohistochemistry: 5-20 ug/mL;. Immunocytochemistry: 5-20 ug/mL;. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot

other info1 :

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: FITC. Traits: Liquid. Unconjugated Antibody: MBS2017615

other info2 :

Immunogen: Recombinant PLA2R1 (Tyr385~Cys643) expressed in E.coli. ( MBS2018771 )

products categories :

FITC Antibody

ncbi gi num :

119631798

ncbi acc num :

EAX11393.1

uniprot acc num :

Q13018

ncbi pathways :

Phagosome Pathway (153910); Phagosome Pathway (153859); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

uniprot summary :

PLA2R1: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q23-q24. Cellular Component: cell surface; integral to plasma membrane; plasma membrane; extracellular region; integral to membrane; receptor complex. Molecular Function: phospholipase binding; receptor activity; carbohydrate binding. Biological Process: receptor-mediated endocytosis; cytokine production; endocytosis; positive regulation of DNA damage response, signal transduction by p53 class mediator

size1 :

0.1 mg

price1 :

260 USD

size2 :

0.2 mg

price2 :

400

size3 :

1 mg

price3 :

955

more info or order :

MyBioSource product webpage