FITC-linked Antibody to Tissue Factor (TF) | MyBioSource MBS2013793 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Tissue Factor (TF)

catalog :

MBS2013793

quantity :

0.1 mg

price :

415 USD

clonality :

polyclonal

host :

guinea pigs

conjugate :

FITC

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2013793

products type :

Antibody

products full name :

FITC-linked Antibody to Tissue Factor (TF)

products short name :

Tissue Factor (TF)

other names :

tissue factor; Tissue factor; tissue factor; coagulation factor III (thromboplastin, tissue factor); Coagulation factor III; Thromboplastin

products gene name :

other gene names :

F3; F3; TF; TFA; CD142; TF

uniprot entry name :

TF_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Cavia

reactivity :

Rabbit

sequence length :

295

specificity :

The antibody is a cavia polyclonal antibody raised against tissue factor. It has been selected for its ability to recognize tissue factor in immunohistochemical staining and western blotting.

purity :

Affinity Chromatography

concentration :

200ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)

app notes :

Western Blot: 1:50-400. ICC in formalin fixed cells: 1:50-500. IHC in formalin fixed frozen section 1:50-500. IHC in paraffin section: 1:10-100. ELISA: 1:100-200

other info1 :

Immunogen: Tissue factor, Rabbit. Recombinant tissue factor (Ala33~Ala292) with two N-terminal Tags, His-tag and S-tag expressed in E Coli. Conjugation: FITC

products categories :

FITC Antibody

ncbi gi num :

339508

ncbi acc num :

AAA36734.1

uniprot acc num :

P13726

ncbi mol weight :

33,068 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (106058); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028)

ncbi summary :

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

uniprot summary :

F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p22-p21. Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding. Biological Process: caspase activation; activation of blood coagulation via clotting cascade; positive regulation of protein kinase B signaling cascade; activation of plasma proteins during acute inflammatory response; positive regulation of angiogenesis; blood coagulation, extrinsic pathway; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration

size1 :

0.1 mg

price1 :

415 USD

more info or order :

MyBioSource product webpage