antibody

FITC-linked Antibody to Heme Oxygenase 2, Decycling (HO2)

MBS2013360

0.1 mg

245 USD

polyclonal

rabbit

FITC

western blot, immunohistochemistry, immunocytochemistry

Antibody

FITC-linked Antibody to Heme Oxygenase 2, Decycling (HO2)

[Heme Oxygenase 2, Decycling (HO2)]

[heme oxygenase 2 isoform b; Heme oxygenase 2; heme oxygenase 2; heme oxygenase (decycling) 2]

[HO2]

[HMOX2; HMOX2; HO-2; HO2; HO-2]

HMOX2_HUMAN

Polyclonal

Rabbit

Human

316

Antigen-specific Affinity Chromatography.

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

200ug/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

Source: Antibody labeling. Label: FITC. Traits: Liquid

Immunogen: Recombinant H02 (Thr71-Leu306) expressed in E.coli.

FITC Antibody

8051608

NP_002125.3

NM_002134.3

P30519

36,033 Da

Heme Degradation Pathway (160971); Iron Uptake And Transport Pathway (187191); Metabolism Pathway (477135); Metabolism Of Porphyrins Pathway (106325); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); Transmembrane Transport Of Small Molecules Pathway (106572); Heme Degradation Pathway (545346)

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HMOX2: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family. Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane. Molecular Function: protein binding; metal ion binding; heme oxygenase (decyclizing) activity. Biological Process: cellular iron ion homeostasis; heme catabolic process; porphyrin metabolic process; response to hypoxia; heme oxidation; transmembrane transport

0.1 mg

245 USD

0.2 mg

365

1 mg

865