antibody

FITC-linked Antibody to Cathepsin K (CTSK)

MBS2013162

0.1 mg

250 USD

polyclonal

unidentified

FITC

western blot, immunohistochemistry, immunocytochemistry

Antibody

FITC-linked Antibody to Cathepsin K (CTSK)

[Cathepsin K (CTSK)]

[cathepsin K preproprotein; Cathepsin K; cathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2; cathepsin K; Cathepsin O; Cathepsin O2; Cathepsin X]

[CTSK]

[CTSK; CTSK; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; CTSO; CTSO2]

CATK_HUMAN

Polyclonal

unknown

329

Antigen-specific Affinity Chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% Glycerol.

0.41 mg/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropiate storage condition. Note: As fluoresce can photobleach when exposed to light, so the antibody must be protected from light.

WB, IHC, ICC, IF

Western Blotting: 0.5-2 ug/mL. Immunohistochemistry: 5-20 ug/mL. Immunocytochemistry: 5-20 ug/mL. Optimal working dilutions must be determined by end user.

. Source: Antibody Labeling . Label: FITC. Traits: Liquid. Immunogen: Recombinant CTSK(Gly113~Asn316) expressed in E.coli.

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2006612

FITC Antibody

4503151

NP_000387.1

NM_000396.3

P43235

Activation Of Matrix Metalloproteinases Pathway (576264); Adaptive Immune System Pathway (366160); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Immune System Pathway (106386); Innate Immune System Pathway (106387); Lysosome Pathway (99052); Lysosome Pathway (96865); MHC Class II Antigen Presentation Pathway (645290)

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family. Protein type: EC 3.4.22.38; Protease. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular space; extracellular region. Molecular Function: collagen binding; protein binding; proteoglycan binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; intramembranous ossification; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; proteolysis; bone resorption. Disease: Pycnodysostosis

0.1 mg

250 USD

0.2 mg

375

1 mg

885