FITC-linked Antibody to Filaggrin (FLG) | MyBioSource MBS2012998 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FITC-linked Antibody to Filaggrin (FLG)

catalog :

MBS2012998

quantity :

0.1 mg

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

(Figure. Western Blot; Sample: Recombinant protein.)

product information

catalog number :

MBS2012998

products type :

Antibody

products full name :

FITC-linked Antibody to Filaggrin (FLG)

products short name :

[Filaggrin (FLG)]

other names :

[filaggrin; Filaggrin; filaggrin; epidermal filaggrin; filaggrin]

products gene name :

[FLG]

other gene names :

[FLG; FLG; ATOD2]

uniprot entry name :

FILA_HUMAN

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.37 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20° for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

Western Blot (WB),Immunohistochemiatry (IHC),Immunocytochemistry (ICC), Immunofluorescence(IF).

app notes :

Western blotting: 0.5-2 ug/mL;1:180-740. Immunohistochemistry: 5-20 ug/mL;1:18-74. Immunocytochemistry: 5-20 ug/mL;1:18-74. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

other info1 :

Organism Species: Mus musculus (Mouse). Source: Antibody labeling. Label: FITC. Traits: Liquid. Immunogen: Recombinant FLG (Asp110~Tyr336) expressed in E.coli.

products categories :

FITC Antibody

ncbi gi num :

60097902

ncbi acc num :

NP_002007.1

ncbi gb acc num :

NM_002016.1

uniprot acc num :

P20930

ncbi pathways :

AhR Pathway (755436)

ncbi summary :

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

uniprot summary :

FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: cytoplasmic membrane-bound vesicle; intermediate filament; nucleus. Molecular Function: protein binding; calcium ion binding; structural molecule activity. Biological Process: keratinocyte differentiation; multicellular organismal development. Disease: Ichthyosis Vulgaris; Dermatitis, Atopic, 2

size1 :

0.1 mg

price1 :

265 USD

size2 :

0.2 mg

price2 :

410

size3 :

1 mg

price3 :

985

more info or order :

MyBioSource product webpage