Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | MyBioSource MBS2012763 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1)

catalog :

MBS2012763

quantity :

0.2 mg

price :

375 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2012763

products type :

Antibody

products full name :

Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1)

products short name :

Lysyl Oxidase Like Protein 1 (LOXL1)

other names :

lysyl oxidase homolog 1 preproprotein; Lysyl oxidase homolog 1; lysyl oxidase homolog 1; lysyl oxidase-like protein 1; lysyl oxidase-like 1; Lysyl oxidase-like protein 1

products gene name :

LOXL1

other gene names :

LOXL1; LOXL1; LOL; LOXL; LOXL; LOL

uniprot entry name :

LOXL1_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

host :

Mouse

reactivity :

Human

sequence length :

574

sequence :

The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF- LP DLVPDPNYVQ ASTYVQRAHL YSLRCAAEEK CLASTAYAPE ATDYDVRVLL RFPQRVKNQG TADFLPNRPR HTWEWHSCHQ HYHSMDEFSH YDLLDAATGK KVAEGHKASF CLEDSTCDFG NLKRYACTSH TQGLSPGCYD TYNADIDCQW IDITDVQPGN YILKVHVNPK YIVLESDFTN NVVRCNIHYT GRYVSATNCK IVQS

specificity :

The antibody is a mouse monoclonal antibody raised against LOXL1. It has been selected for its ability to recognize LOXL1 in immunohistochemical staining andwestern blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

concentration :

500ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200

other info1 :

UOM: 2001-19

ncbi gi num :

67782346

ncbi acc num :

NP_005567.2

ncbi gb acc num :

NM_005576.2

uniprot acc num :

Q08397

ncbi mol weight :

63,110 Da

ncbi pathways :

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Crosslinking Of Collagen Fibrils Pathway (730308); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262)

ncbi summary :

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

uniprot summary :

LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family. Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Oxidoreductase; EC 1.4.3.-. Chromosomal Location of Human Ortholog: 15q22. Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane. Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination. Disease: Exfoliation Syndrome

size1 :

0.2 mg

price1 :

375 USD

more info or order :

MyBioSource product webpage