protein

Recombinant Relaxin 2 (RLN2)

MBS2012369

0.01 mg

140 USD

Recombinant Protein

Recombinant Relaxin 2 (RLN2)

[Relaxin 2 (RLN2)]

[prorelaxin H2 isoform 2; Prorelaxin H2; prorelaxin H2; H2-preprorelaxin; relaxin, ovarian, of pregnancy; relaxin 2]

[RLN2]

[RLN2; RLN2; H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2]

REL2_HUMAN

E Coli

Homo sapiens (Human)

> 95%

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, WB, ELISA, IP, CoIP, ReporterAssays, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Source: Prokaryotic expression. Residues: Met1~Cys186. Tags: N-terminal His-Tag. Tissue Specificity: Brain, Prostate Gland. Subcellular Location: Secreted. Traits: Freeze-dried powder

Predicted isoelectric point: 6.7. Predicted Molecular Mass: 22.3kDa. Accurate Molecular Mass: 22kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

20143935

NP_005050.2

NM_005059.3

P04090

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Peptide Ligand-binding Receptors Pathway (106358); Relaxin Receptors Pathway (161022); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

RLN2: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular region. Molecular Function: hormone activity. Biological Process: female pregnancy

0.01 mg

140 USD

0.05 mg

270

0.1 mg

420

0.2 mg

515

0.5 mg

990

1 mg

1475