Recombinant Growth Differentiation Factor 1 (GDF1) | MyBioSource MBS2012351 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Growth Differentiation Factor 1 (GDF1)

catalog :

MBS2012351

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2012351

products type :

Recombinant Protein

products full name :

Recombinant Growth Differentiation Factor 1 (GDF1)

products short name :

[Growth Differentiation Factor 1 (GDF1)]

other names :

[embryonic growth/differentiation factor 1; Embryonic growth/differentiation factor 1; embryonic growth/differentiation factor 1; growth differentiation factor 1]

products gene name :

[GDF1]

other gene names :

[Gdf1; Gdf1; Gdf-1; AI385651; Gdf-1; GDF-1]

uniprot entry name :

GDF1_MOUSE

host :

E.coli

reactivity :

Mouse

purity :

> 95%

form :

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Cys230~Arg357. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 8.3. Predicted Molecular Mass: 15.6kDa. Accurate Molecular Mass: 17kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex

ncbi gi num :

253970469

ncbi acc num :

NP_001156754.1

ncbi gb acc num :

NM_001163282.2

uniprot acc num :

P20863

ncbi pathways :

Developmental Biology Pathway (926382); Signaling By NODAL Pathway (926418)

ncbi summary :

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes the LAG1 homolog, ceramide synthase 1 gene. [provided by RefSeq, Jul 2009]

uniprot summary :

GDF1: May mediate cell differentiation events during embryonic development. Defects in GDF1 are a cause of conotruncal heart malformations (CTHM). A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Defects in GDF1 are a cause of tetralogy of Fallot (TOF). A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space. Molecular Function: cytokine activity; transforming growth factor beta receptor binding. Biological Process: BMP signaling pathway; regulation of apoptosis; in utero embryonic development; regulation of MAPKKK cascade; mesoderm development; signal transduction; cell development; endoderm development

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

280

size3 :

0.1 mg

price3 :

430

size4 :

0.2 mg

price4 :

530

size5 :

0.5 mg

price5 :

1020

size6 :

1 mg

price6 :

1520

more info or order :

MyBioSource product webpage