protein

Recombinant Inhibin Beta E (INHbE)

MBS2012336

0.01 mg

130 USD

Recombinant Protein

Recombinant Inhibin Beta E (INHbE)

[Inhibin Beta E (INHbE)]

[inhibin beta E chain; Inhibin beta E chain; inhibin beta E chain; activin beta E; activin beta-E chain; inhibin, beta E; Activin beta-E chain]

[INHbE]

[INHBE; INHBE]

INHBE_HUMAN

E.coli

>95%

PBS, pH7.4, containing 0.01% sarcosyl and 20% glycerin.

300ug/mL

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE;Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Thr237~Ser350. Tags: N-terminal His-Tag . Tissue Specificity: Liver, Muscle. Subcellular Location: Secreted. Traits: Liquid

Predicted isoelectric point: 6.2. Predicted Molecular Mass: 13.7kDa. Accurate Molecular Mass: 17&18kDa as determined by SDS-PAGE reducing conditions. Phenomenon explanation: The possible reasons that the actual band size differs from the predicted are as follows: . 1. Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form. 5. Polymerization of the target protein: Dimerization, multimerization etc.

13899338

NP_113667.1

NM_031479.3

P58166

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Glycoprotein Hormones Pathway (160989); Metabolism Of Proteins Pathway (106230); Peptide Hormone Biosynthesis Pathway (160988); Peptide Hormone Metabolism Pathway (771603); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

INHBE is a member of the activin beta family (see INHBA; MIM 147290) that plays a role in pancreatic exocrine cell growth and proliferation (Hashimoto et al., 2006 [PubMed 16426570]).[supplied by OMIM, May 2008]

INHBE: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: extracellular space. Molecular Function: growth factor activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: regulation of apoptosis; regulation of MAPKKK cascade; cell development; growth

0.01 mg

130 USD

0.05 mg

225

0.1 mg

340

0.2 mg

415

0.5 mg

800

1 mg

1180