protein

Recombinant Corticosteroid Binding Globulin (CBG)

MBS2012320

0.01 mg

185 USD

Recombinant Protein

Recombinant Corticosteroid Binding Globulin (CBG)

Corticosteroid Binding Globulin (CBG)

corticosteroid-binding globulin; Corticosteroid-binding globulin; corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; Serpin A6; Transcortin

CBG

SERPINA6; SERPINA6; CBG; CBG; CBG

CBG_HUMAN

E Coli

Homo sapiens (Human)

405

The sequence of the target protein is listed below. EEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT AGSTGVTLNL TSKPIILR

> 95%

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Expression System: Prokaryotic expression. Residues: Glu218~Arg378 (Accession # P08185) with N-terminal His-Tag. Predicted Isoelectric Point: 5.5. Subcellular Location: Secreted.

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in ddH2O

73858564

NP_001747.2

NM_001756.3

P08185

19.2kDa

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: extracellular space. Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding. Biological Process: glucocorticoid metabolic process; transport. Disease: Corticosteroid-binding Globulin Deficiency

0.01 mg

185 USD

0.05 mg

380

0.1 mg

585