catalog number :
MBS2012307
products type :
Recombinant Protein
products full name :
Recombinant FK506 Binding Protein 5 (FKBP5)
products short name :
[FK506 Binding Protein 5 (FKBP5)]
other names :
[peptidyl-prolyl cis-trans isomerase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidyl-prolyl cis-trans isomerase FKBP5; rotamase; 51 kDa FKBP; PPIase FKBP5; 51 kDa FK506-binding protein; FK506 binding protein 5; 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; FK506-binding protein 5; FKBP-5; Rotamase]
products gene name :
[FKBP5]
other gene names :
[Fkbp5; Fkbp5; Dit1; FKBP-5; FKBP51; D17Ertd592e; Fkbp51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5]
uniprot entry name :
FKBP5_MOUSE
form :
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose.
concentration :
Original Concentration: 200 ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control (PC), Immunogen, SDS-PAGE, Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
Sequence Information
image2 heading :
SDS-PAGE
other info1 :
Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Thr2~Val456. Tags: N-terminal His Tag. Subcellular Location: Nucleus, Cytoplasm. Traits: Freeze-dried powder. Predicted isoelectric point: 7.6. Usage: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_034350.1
ncbi gb acc num :
NM_010220.4
ncbi mol weight :
Predicted isoelectric point: 7.6. Predicted Molecular Mass: 52.1 kDa. Accurate Molecular Mass: 52 kDa as determined by SDS-PAGE reducing conditions.
ncbi pathways :
Estrogen Signaling Pathway (799184); Estrogen Signaling Pathway (799197); TNF-alpha NF-kB Signaling Pathway (198358)
uniprot summary :
FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. Protein type: Chaperone; EC 5.2.1.8; Isomerase. Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; cytoplasm; nucleus. Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding; isomerase activity. Biological Process: protein peptidyl-prolyl isomerization; protein folding