Recombinant Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) | MyBioSource MBS2012305 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2)

catalog :

MBS2012305

quantity :

0.01 mg

price :

150 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2012305

products type :

Recombinant Protein

products full name :

Recombinant Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2)

products short name :

[Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2)]

other names :

[killer cell immunoglobulin-like receptor 2DS2; Killer cell immunoglobulin-like receptor 2DS2; killer cell immunoglobulin-like receptor 2DS2; NKAT-5; p58 KIR; 1060P11.9.2; NK receptor 183 ActI; p58 NK receptor CL-49; MHC class I NK cell receptor; killer-cell Ig-like receptor; CD158 antigen-like family member J; natural killer associated transcript 5; natural killer-associated transcript 5; natural killer cell inhibitory receptor; p58 killer cell inhibitory receptor KIR-K7a; p58 natural killer cell receptor clone CL-49; killer-cell immunoglobulin-like receptor two domains short tail 2 protein; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2; CD158 antigen-like family member J; MHC class I NK cell receptor; NK receptor 183 ActI; Natural killer-associated transcript 5; NKAT-5; p58 natural killer cell receptor clone CL-49]

products gene name :

[KIR2DS2]

other gene names :

[KIR2DS2; KIR2DS2; NKAT5; cl-49; CD158J; CD158b; 183ActI; CD158J; NKAT5; NKAT-5]

uniprot entry name :

KI2S2_HUMAN

host :

E Coli

sequence length :

304

purity :

> 95%

form :

Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.

concentration :

Original Concentration: 200 Ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

. Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: His22~Ala304. Tags: N-terminal His and GST Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT,0.01% SKL, 5% Trehalose and Proclin300.

other info2 :

. Predicted isoelectric point: 6.3. Predicted Molecular Mass: 61.2kDa. Accurate Molecular Mass: 60kDa as determined by SDS-PAGE reducing conditions. USAGE: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

6912472

ncbi acc num :

NP_036444.1

ncbi gb acc num :

NM_012312.3

uniprot acc num :

P43631

ncbi pathways :

Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490)

ncbi summary :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

uniprot summary :

KIR2DS2: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: integral to membrane; plasma membrane. Molecular Function: transmembrane receptor activity. Biological Process: regulation of immune response; innate immune response; immune response; signal transduction

size1 :

0.01 mg

price1 :

150 USD

size2 :

0.05 mg

price2 :

290

size3 :

0.1 mg

price3 :

455

size4 :

0.2 mg

price4 :

560

size5 :

0.5 mg

price5 :

1080

size6 :

1 mg

price6 :

1610

more info or order :

MyBioSource product webpage