protein

Recombinant Lysyl Oxidase (LOX)

MBS2012304

0.01 mg

185 USD

Recombinant Protein

Recombinant Lysyl Oxidase (LOX)

Lysyl Oxidase (LOX)

protein-lysine 6-oxidase preproprotein; Protein-lysine 6-oxidase; protein-lysine 6-oxidase; ras recision; ras excision protein; lysyl oxidase; Lysyl oxidase; Ras excision protein

LOX

Lox; Lox; rrg; TSC-160; AI893619; Rrg

LYOX_MOUSE

E. coli

Mouse

>92%

20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.

200 ug/ml

Storage : Avoid repeated freeze/thaw cycles.Store at 2-8 degree C for one month.Aliquot and store at -80 degree C for 12 months. Stability Test : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)

Source: Prokaryotic expression. Residues: Pro207~Tyr411. Tags: Two N-terminal Tags, His-tag and GST-tag. Subcellular Location: Secreted, extracellular space. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300

Predicted isoelectric point: 6.1. Predicted Molecular Mass: 55.4kDa. Accurate Molecular Mass: 54kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

555943929

NP_001273110.1

NM_001286181.1

P28301

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (927064); Collagen Formation Pathway (927062); Crosslinking Of Collagen Fibrils Pathway (927066); Elastic Fibre Formation Pathway (927068); Extracellular Matrix Organization Pathway (927061)

This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family. Protein type: Secreted; Secreted, signal peptide; EC 1.4.3.13; Oxidoreductase. Cellular Component: proteinaceous extracellular matrix; collagen; extracellular region; nucleus. Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Biological Process: blood vessel development; elastic fiber assembly; collagen fibril organization; wound healing; response to steroid hormone stimulus; response to hormone stimulus; lung development

0.01 mg

185 USD

0.05 mg

380

0.1 mg

585