Recombinant Granulin (GRN) | MyBioSource MBS2012256 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Granulin (GRN)

catalog :

MBS2012256

quantity :

0.01 mg

price :

100 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

Sequence

product information

catalog number :

MBS2012256

products type :

Recombinant Protein

products full name :

Recombinant Granulin (GRN)

products short name :

[Granulin (GRN)]

other names :

[granulins; Granulins; granulins; acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor; granulin; Proepithelin; PEPICleaved into the following 9 chains:Acrogranin; Alternative name(s):; Glycoprotein of 88 Kda; ProgranulinParagranulinGranulin-1; Alternative name(s):; Granulin GGranulin-2; Alternative name(s):; Granulin FGranulin-3; Alternative name(s):; Granulin BGranulin-4; Alternative name(s):; Granulin AGranulin-5; Alternative name(s):; Granulin CGranulin-6; Alternative name(s):; Granulin DGranulin-7; Alternative name(s):; Granulin E]

products gene name :

[GRN]

other gene names :

[GRN; GRN; GEP; GP88; PEPI; PGRN; CLN11; PCDGF; PEPI]

uniprot entry name :

GRN_HUMAN

host :

E.coli

purity :

>90%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage:. Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB).

image1 heading :

SDS-Page

image2 heading :

Testing Data (TD)

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Pro21~Ser120. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 6.9. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

4504151

ncbi acc num :

NP_002078.1

ncbi gb acc num :

NM_002087.2

uniprot acc num :

P28799

ncbi mol weight :

Predicted Molecular Mass: 16.1kDa. Accurate Molecular Mass: 18kDa as determined by SDS-PAGE reducing conditions.

ncbi pathways :

Integrated Breast Cancer Pathway (219801)

ncbi summary :

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

uniprot summary :

GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: extracellular space; mitochondrion; intracellular membrane-bound organelle. Molecular Function: protein binding; growth factor activity; cytokine activity. Biological Process: blastocyst hatching; signal transduction; positive regulation of epithelial cell proliferation; embryo implantation. Disease: Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Ceroid Lipofuscinosis, Neuronal, 11

size1 :

0.01 mg

price1 :

100 USD

size2 :

0.05 mg

price2 :

155

size3 :

0.1 mg

price3 :

210

size4 :

0.2 mg

price4 :

250

size5 :

0.5 mg

price5 :

470

size6 :

1 mg

price6 :

690

more info or order :

MyBioSource product webpage