Recombinant Collagen Type XVII (COL17) | MyBioSource MBS2012222 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Collagen Type XVII (COL17)

catalog :

MBS2012222

quantity :

0.01 mg

price :

135 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2012222

products type :

Recombinant Protein

products full name :

Recombinant Collagen Type XVII (COL17)

products short name :

[Collagen Type XVII (COL17)]

other names :

[collagen alpha-1(XVII) chain; Collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); collagen, type XVII, alpha 1; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2Cleaved into the following 2 chains:120 kDa linear IgA disease antigen; Alternative name(s):; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-197 kDa linear IgA disease antigen; Alternative name(s):; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa]

products gene name :

[COL17]

other gene names :

[COL17A1; COL17A1; BP180; BPA-2; BPAG2; LAD-1; BA16H23.2; BP180; BPAG2; LAD-1; 97 kDa LAD antigen; 97-LAD; LABD97]

uniprot entry name :

COHA1_HUMAN

host :

E Coli

purity :

> 97%

concentration :

Original concentration: 200 ug/mL

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), Immunogen, Positive Control. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Pro184~Pro375. Tags: N-terminal His Tag . Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Predicted isoelectric point: 7.2. Predicted Molecular Mass: 21.2kDa . Accurate Molecular Mass: 23kDa as determined by SDS-PAGE reducing conditions. Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

119829187

ncbi acc num :

NP_000485.3

ncbi gb acc num :

NM_000494.3

uniprot acc num :

Q9UMD9

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)

ncbi summary :

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]

uniprot summary :

COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Extracellular matrix; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 10q24.3. Cellular Component: collagen; hemidesmosome; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; extracellular region; basement membrane; intercellular junction. Molecular Function: protein binding. Biological Process: collagen catabolic process; extracellular matrix disassembly; epidermis development; hemidesmosome assembly; extracellular matrix organization and biogenesis; cell-matrix adhesion. Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type

size1 :

0.01 mg

price1 :

135 USD

size2 :

0.05 mg

price2 :

250

size3 :

0.1 mg

price3 :

385

size4 :

0.2 mg

price4 :

470

size5 :

0.5 mg

price5 :

910

size6 :

1 mg

price6 :

1345

more info or order :

MyBioSource product webpage