Recombinant Selenoprotein P1, Plasma (SEPP1) | MyBioSource MBS2012091 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Selenoprotein P1, Plasma (SEPP1)

catalog :

MBS2012091

quantity :

0.01 mg

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2012091

products type :

Recombinant Protein

products full name :

Recombinant Selenoprotein P1, Plasma (SEPP1)

products short name :

Selenoprotein P1, Plasma (SEPP1)

other names :

selenoprotein P isoform 1; Selenoprotein P; selenoprotein P; selenoprotein P, plasma, 1

products gene name :

SEPP1

other gene names :

SEPP1; SEPP1; SeP; SELP; SELP; SeP

uniprot entry name :

SEPP1_HUMAN

host :

E Coli

sequence length :

381

sequence :

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-Y LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY THLKNKVSEH IPVYQQEENQ TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL KDEDFCKRVS LATVDKTVET PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP PGLHHHHKHK GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRS

purity :

> 95%

form :

Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH 8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Tyr60~Ser299 (Accession # P49908) with N-terminal His-Tag. Subcellular Location: Secreted. Accurate Molecular Mass: 33kDa as determined by SDS-PAGE reducing conditions.

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted Isoelectric Point: 7.7. Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

148277018

ncbi acc num :

NP_001078955.1

ncbi gb acc num :

NM_001085486.1

uniprot acc num :

P49908

ncbi mol weight :

29.1kDa

ncbi pathways :

Integrin-mediated Cell Adhesion Pathway (198816); Selenium Metabolism And Selenoproteins Pathway (198846); Selenium Pathway (198825)

ncbi summary :

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SEPP1: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. Belongs to the selenoprotein P family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: extracellular space; extracellular region. Molecular Function: selenium binding. Biological Process: sexual reproduction; locomotory behavior; response to oxidative stress; brain development; selenium metabolic process; post-embryonic development; growth

size1 :

0.01 mg

price1 :

175 USD

size2 :

0.05 mg

price2 :

370

size3 :

0.1 mg

price3 :

575

more info or order :

MyBioSource product webpage