protein

Recombinant Growth Arrest Specific Protein 6 (GAS6)

MBS2012078

0.01 mg

185 USD

Recombinant Protein

Recombinant Growth Arrest Specific Protein 6 (GAS6)

Growth Arrest Specific Protein 6 (GAS6)

Growth arrest-specific protein 6; Growth arrest-specific protein 6; growth arrest-specific protein 6; GPF; GAS-6; growth-potentiating factor; AXL receptor tyrosine kinase ligand; growth arrest specific 6; AXL receptor tyrosine kinase ligand; Growth-potentiating factor

GAS6

Gas6; Gas6; GAS-6; GPF

GAS6_RAT

E Coli

674

The sequence of the target protein is listed below. E DKNPNFATCV KNLPDQCTPN PCDKKGTQLC QDLMGNFFCL CKDGWGGRLC DKDVNECSQK NGGCSQVCHN KPGSFQCACH SGFSLQSDNK SCQDIDECTD SDTCGDARCK NLPGSYSCLC DKGYTYSSKE KTCQDVDECQ QDRCEQTCVN SPGSYTCHCN GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG TPVIRLRFKR LQ

> 95%

Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Organism: Rattus norvegicus (Rat). Expression System: Prokaryotic expression. Residues: Glu100~Gln312 (Accession # Q63772) with N-terminal His-Tag

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in ddH2O. Predicted isoelectric point: 6.3. Accurate Molecular Mass: 28kDa as determined by SDS-PAGE reducing conditions.

48427855

Q63772.1

Q63772

25.0kDa

Cell Surface Interactions At The Vascular Wall Pathway (935750); Gamma-carboxylation Of Protein Precursors Pathway (935821); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (935820); Hemostasis Pathway (935717); Metabolism Of Proteins Pathway (935800); PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (935819); Platelet Activation, Signaling And Aggregation Pathway (935727); Platelet Degranulation Pathway (935744); Post-translational Protein Modification Pathway (935818); Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway (935823)

provides protection of neurons against serum deprivation-induced apoptosis [RGD, Feb 2006]

GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Ligand, receptor tyrosine kinase; Secreted. Cellular Component: extracellular space; cytoplasm; extracellular region; intracellular. Molecular Function: voltage-gated calcium channel activity; growth factor activity; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding. Biological Process: entry of virus into host cell; tissue remodeling; neuron migration; negative regulation of caspase activity; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; positive regulation of glomerular filtration; tissue regeneration; negative regulation of interferon-gamma production; regulation of growth; positive regulation of phagocytosis; protein kinase B signaling cascade; negative regulation of interleukin-6 production; positive regulation of TOR signaling pathway; virion attachment, binding of host cell surface receptor; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; viral genome replication; negative regulation of tumor necrosis factor production; cellular response to starvation; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; negative regulation of interleukin-1 secretion; apoptotic cell clearance; negative regulation of apoptosis

0.01 mg

185 USD

0.05 mg

385

0.1 mg

595