Recombinant Growth Arrest Specific Protein 6 (GAS6) | MyBioSource MBS2011932 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Growth Arrest Specific Protein 6 (GAS6)

catalog :

MBS2011932

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2011932

products type :

Recombinant Protein

products full name :

Recombinant Growth Arrest Specific Protein 6 (GAS6)

products short name :

[Growth Arrest Specific Protein 6 (GAS6)]

other names :

[growth arrest-specific protein 6 isoform 1; Growth arrest-specific protein 6; growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand; growth arrest-specific 6; AXL receptor tyrosine kinase ligand]

products gene name :

[GAS6]

other gene names :

[GAS6; GAS6; AXSF; AXLLG; AXLLG; GAS-6]

uniprot entry name :

GAS6_HUMAN

host :

E Coli

sequence length :

678

sequence :

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF-LMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM FSGTPVIRLR F

purity :

>90%

form :

Supplied as lyophilized form in 10mM PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Leu136~Phe311 (Accession # Q14393) with N-terminal His-Tag

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Predicted isoelectric point: 5.6. Predicted Molecular Mass: 20.7kDa. Reconstitution: Reconstitute in ddH2O.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

4557617

ncbi acc num :

NP_000811.1

ncbi gb acc num :

NM_000820.2

uniprot acc num :

Q14393

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Gamma-carboxylation Of Protein Precursors Pathway (106233); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Hemostasis Pathway (106028); Metabolism Of Proteins Pathway (106230); PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (106231); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Post-translational Protein Modification Pathway (161012); Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway (106235)

ncbi summary :

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

uniprot summary :

GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; cytoplasm; extracellular region. Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding. Biological Process: proteolysis; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; regulation of growth; positive regulation of phagocytosis; negative regulation of interleukin-6 production; cell cycle arrest; cell adhesion; positive regulation of TOR signaling pathway; platelet activation; organ regeneration; negative regulation of transcription factor activity; activation of protein kinase B; cellular response to starvation; peptidyl-glutamic acid carboxylation; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of interleukin-1 secretion; negative regulation of apoptosis; entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; platelet degranulation; positive regulation of glomerular filtration; negative regulation of interferon-gamma production; protein kinase B signaling cascade; virion attachment, binding of host cell surface receptor; cell migration; viral genome replication; negative regulation of tumor necrosis factor production; post-translational protein modification; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; apoptotic cell clearance

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

280

size3 :

0.1 mg

price3 :

440

size4 :

0.2 mg

price4 :

540

size5 :

0.5 mg

price5 :

1040

size6 :

1 mg

price6 :

1545

more info or order :

MyBioSource product webpage