Recombinant Heat Shock 70kDa Protein 1A (HSPA1A) | MyBioSource MBS2011931 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Heat Shock 70kDa Protein 1A (HSPA1A)

catalog :

MBS2011931

quantity :

0.01 mg

price :

115 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2011931

products type :

Recombinant Protein

products full name :

Recombinant Heat Shock 70kDa Protein 1A (HSPA1A)

products short name :

[Heat Shock 70kDa Protein 1A (HSPA1A)]

other names :

[heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A; 68 kDa heat shock protein; heat shock 70 kDa protein 3; heat shock 70kDa protein 1A; heat shock protein, 70 kDa 3; inducible heat shock protein 70; heat shock protein 1A; Heat shock 70 kDa protein 3; HSP70.3; Hsp68]

products gene name :

[HSPA1A]

other gene names :

[Hspa1a; Hspa1a; Hsp72; hsp68; Hsp70-3; Hsp70.3; hsp70A1; Hsp70-3; Hsp70A1; HSP70.3]

uniprot entry name :

HS71A_MOUSE

host :

E. coli

reactivity :

Mouse

purity :

> 95%

form :

PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.

concentration :

200ug/mL

storage stability :

Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Met1~Asp641. Tags: N-terminal His-Tag. Tissue Specificity: Liver, Brain. Subcellular location: Cytoplasm. Traits: Freeze-dried powder.

other info2 :

Predicted isoelectric point: 5.7. Predicted Molecular Mass: 71.3kDa. Accurate Molecular Mass: 74kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex

ncbi gi num :

124339829

ncbi acc num :

NP_034609.2

ncbi gb acc num :

NM_010479.2

uniprot acc num :

Q61696

ncbi pathways :

Androgen Receptor Signaling Pathway (198319); Antigen Processing And Presentation Pathway (83271); Antigen Processing And Presentation Pathway (485); Apoptosis Modulation By HSP70 Pathway (198355); Destabilization Of MRNA By AUF1 (hnRNP D0) Pathway (927246); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Epstein-Barr Virus Infection Pathway (585576); Epstein-Barr Virus Infection Pathway (587115); Estrogen Signaling Pathway (799184)

uniprot summary :

HSP70: a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, hsp70 stabilizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Mitochondrial HSP70 is crucial to the import process: mutant forms of HSP70 fail to import precursor proteins. Is anti-apoptotic in sympathetic neurones and mediates this effect primarily by suppressing c-Jun transcriptional signalling. Interacts with tau protein and mediates proper folding of tau. Can promote the degradation of tau protein. Triptolide, a potential therapeutic agent for progression/metastasis of pancreatic cancer, causes pancreatic cancer cell death by induction of apoptosis, an effect mediated by the inhibition of HSP70. Protein type: Heat shock protein; Chaperone; Motility/polarity/chemotaxis. Cellular Component: signalosome; focal adhesion; protein complex; mitochondrion; basolateral plasma membrane; inclusion body; cytosol; ribonucleoprotein complex; centriole; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nuclear speck; nucleus; vesicle; ubiquitin ligase complex. Molecular Function: NF-kappaB binding; enzyme binding; protease binding; G-protein-coupled receptor binding; ubiquitin protein ligase binding; heat shock protein binding; unfolded protein binding; ATPase activity; double-stranded RNA binding; protein N-terminus binding; ATPase activity, coupled; ATP binding. Biological Process: protein folding; response to heat; DNA repair; telomere maintenance

size1 :

0.01 mg

price1 :

115 USD

size2 :

0.05 mg

price2 :

200

size3 :

0.1 mg

price3 :

290

size4 :

0.2 mg

price4 :

360

size5 :

0.5 mg

price5 :

690

size6 :

1 mg

price6 :

1015

more info or order :

MyBioSource product webpage