Recombinant Corin (CRN) | MyBioSource MBS2011896 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Corin (CRN)

catalog :

MBS2011896

quantity :

0.01 mg

price :

150 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2011896

products type :

Recombinant Protein

products full name :

Recombinant Corin (CRN)

products short name :

[Corin (CRN)]

other names :

[atrial natriuretic peptide-converting enzyme; Atrial natriuretic peptide-converting enzyme; atrial natriuretic peptide-converting enzyme; pro-ANP-converting enzyme; corin, serine peptidase; Corin; Pro-ANP-converting enzyme]

products gene name :

[CRN]

other gene names :

[Corin; Corin]

uniprot entry name :

CORIN_RAT

host :

E Coli

reactivity :

Rattus norvegicus (Rat)

purity :

> 98%

form :

PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarkosyl and Proclin300.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, WB, ELISA, IP, CoIP, ReporterAssays, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Tissue Specificity: Heart. Residues: Pro533~Gln634 (Accession # Q80YN4) with N-terminal His-Tag. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle. Predicted isoelectric point: 6.1. Predicted Molecular Mass: 13.2kDa . Accurate Molecular Mass: 14kDa as determined by SDS-PAGE reducing conditions.

other info2 :

Traits: Freeze-dried powder. Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

32563562

ncbi acc num :

NP_872279.1

ncbi gb acc num :

NM_182473.1

uniprot acc num :

Q80YN4

ncbi pathways :

Myometrial Relaxation And Contraction Pathways (198465)

uniprot summary :

Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Ref.3 Ref.4. Subcellular location: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle Ref.3 Ref.4. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted . By similarity. Note: Soluble form produced following cleavage by ADAM10 . By similarity. Ref.3 Ref.4. Tissue specificity: Specifically expressed in heart. Also detected in kidney, aorta, brain and testis. In kidney, present in epithelial cells, with segmental expression in the proximal tubule, thick ascending limb, connecting tubule, and throughout the collecting duct (at protein level). Ref.1. Induction: Down-regulated upon experimental heart failure. Ref.1. Post-translational modification: N-glycosylated; required for processing and activation. Ref.3Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 . Probable. Ref.3A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment . Probable. Sequence similarities: Belongs to the peptidase S1 family.Contains 2 FZ (frizzled) domains.Contains 7 LDL-receptor class A domains.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.

size1 :

0.01 mg

price1 :

150 USD

size2 :

0.05 mg

price2 :

290

size3 :

0.1 mg

price3 :

455

size4 :

0.2 mg

price4 :

560

size5 :

0.5 mg

price5 :

1080

size6 :

1 mg

price6 :

1610

more info or order :

MyBioSource product webpage