Recombinant Complement Factor B (CFB) | MyBioSource MBS2011759 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Complement Factor B (CFB)

catalog :

MBS2011759

quantity :

0.01 mg

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2011759

products type :

Recombinant Protein

products full name :

Recombinant Complement Factor B (CFB)

products short name :

Complement Factor B (CFB)

other names :

Complement factor B; Complement factor B; complement factor B; Factor B; properdin; C3/C5 convertase; complement component 2 (within H-2S); alternative-complement pathway C3/C5 convertase; histocompatibility 2, complement component factor B; complement factor B; C3/C5 convertase

products gene name :

CFB

other gene names :

Cfb; Cfb; B; Bf; C2; Fb; H2-Bf; AI195813; AI255840; Bf; H2-Bf

uniprot entry name :

CFAB_MOUSE

host :

E Coli

sequence length :

761

sequence :

The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF-LCGMVWEHKK GNDYHKQPWQ AKISVTRPLK GHETCMGAVV SEYFVLTAAH CFMVDDQKHS IKVSVGGQRR DLEIEEVLFH PKYNINGKKA EGIPEFYDYD VALVKLKNKL KYGQTLR

purity :

> 95%

form :

Supplied as lyophilized form in 10mM PBS, pH 7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Leu474~Arg590 (Accession # P04186) with N-terminal His-Tag. Predicted Molecular Mass: 15 kDa

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile ddH2O. Predicted Isoelectric Point: 8.7

ncbi gi num :

116126

ncbi acc num :

P04186.2

uniprot acc num :

P04186

ncbi mol weight :

15.0kDa

ncbi pathways :

Activation Of C3 And C5 Pathway (926093); Alternative Complement Activation Pathway (926092); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (926086); Immune System Pathway (926012); Initial Triggering Of Complement Pathway (926087); Innate Immune System Pathway (926045); Regulation Of Complement Cascade Pathway (926095)

uniprot summary :

CFB: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; EC 3.4.21.47; Protease; Secreted. Cellular Component: extracellular space; extracellular region. Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity. Biological Process: cell proliferation; immune system process; complement activation, alternative pathway; innate immune response; proteolysis; complement activation

size1 :

0.01 mg

price1 :

175 USD

size2 :

0.05 mg

price2 :

370

size3 :

0.1 mg

price3 :

575

more info or order :

MyBioSource product webpage