Recombinant S100 Calcium Binding Protein B (S100B) | MyBioSource MBS2011650 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant S100 Calcium Binding Protein B (S100B)

catalog :

MBS2011650

quantity :

0.01 mg

price :

170 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2011650

products type :

Recombinant Protein

products full name :

Recombinant S100 Calcium Binding Protein B (S100B)

products short name :

S100 Calcium Binding Protein B (S100B)

other names :

protein S100-B; Protein S100-B; protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100 protein, beta polypeptide, neural; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

products gene name :

S100B

other gene names :

S100b; S100b; Bpb; AI850290

uniprot entry name :

S100B_MOUSE

host :

E Coli

purity :

>92%

form :

PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)

app notes :

Accurate protein sizing on SDS-polyacrylamide gels and Western Blots

other info1 :

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Met1~Glu92 with N-terminal His-Tag. Tissue Specificity: Brain. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 4.9. Predicted Molecular Mass: 12.0kDa. Accurate Molecular Mass: 10kDa as determined by SDS-PAGE reducing conditions. Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex. Subcellular Location: Cytoplasm. Nucleus.

ncbi gi num :

6677839

ncbi acc num :

NP_033141.1

ncbi gb acc num :

NM_009115.3

uniprot acc num :

P50114

ncbi pathways :

Activated TLR4 Signalling Pathway (926081); Advanced Glycosylation Endproduct Receptor Signaling Pathway (926102); Cytosolic Sensors Of Pathogen-associated DNA Pathway (926112); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (926120); Immune System Pathway (926012); Innate Immune System Pathway (926045); MyD88 Cascade Initiated On Plasma Membrane Pathway (926049); MyD88 Dependent Cascade Initiated On Endosome Pathway (926073); MyD88-independent Cascade Pathway (926065); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (926082)

uniprot summary :

S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family. Protein type: Calcium-binding. Cellular Component: ruffle; extracellular space; cell soma; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus. Molecular Function: identical protein binding; RAGE receptor binding; protein homodimerization activity; zinc ion binding; metal ion binding; calcium ion binding; calcium-dependent protein binding; receptor binding. Biological Process: cellular calcium ion homeostasis; regulation of long-term neuronal synaptic plasticity; regulation of cell shape; positive regulation of I-kappaB kinase/NF-kappaB cascade; learning and/or memory; positive regulation of apoptosis; positive regulation of cell proliferation; energy reserve metabolic process; memory; positive regulation of synaptic transmission; regulation of cytokine biosynthetic process; regulation of neuronal synaptic plasticity

size1 :

0.01 mg

price1 :

170 USD

size2 :

0.05 mg

price2 :

345

size3 :

0.1 mg

price3 :

535

more info or order :

MyBioSource product webpage