protein

Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)

MBS2011613

0.01 mg

145 USD

Recombinant Protein

Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)

[Cardiotrophin Like Cytokine Factor 1 (CLCF1)]

[cardiotrophin-like cytokine factor 1; Cardiotrophin-like cytokine factor 1; cardiotrophin-like cytokine factor 1; BSF-3; NNT-1; NNT-1/BSF-3; novel neurotrophin-1; B-cell stimulating factor 3; B-cell-stimulating factor 3; b cell-stimulating factor 3; neurotrophin-1/B-cell stimulating factor-3; cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1]

[CLCF1]

[Clcf1; Clcf1; CLC; Bsf3; Bsf3; Nnt1; BSF-3; NNT-1]

CLCF1_MOUSE

E.coli

> 97%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Original Concentration: 200ug/mL

Storage:. Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Leu28~Phe225. Tags: N-terminal His Tag. Subcellular Location: Secreted

Traits: Freeze-dried powder. Predicted isoelectric point: 9.3. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

9910314

NP_064336.1

NM_019952.3

Q9QZM3

Predicted Molecular Mass: 26.2kDa. Accurate Molecular Mass: 26kDa as determined by SDS-PAGE reducing conditions.

Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Jak-STAT Signaling Pathway (83274); Jak-STAT Signaling Pathway (488)

CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Cytokine; Secreted, signal peptide; Apoptosis. Cellular Component: extracellular space; extracellular region; intracellular. Molecular Function: protein binding; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding. Biological Process: positive regulation of T-helper 2 type immune response; regulation of protein kinase B signaling cascade; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of corticotropin-releasing hormone secretion; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; regulation of inflammatory response; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation

0.01 mg

145 USD

0.05 mg

280

0.1 mg

435

0.2 mg

535

0.5 mg

1035

1 mg

1540