protein

Recombinant Surfactant Associated Protein C (SPC)

MBS2011501

0.01 mg

145 USD

Recombinant Protein

Recombinant Surfactant Associated Protein C (SPC)

[Surfactant Associated Protein C (SPC)]

[Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SP5]

[SPC]

[Sftpc; Sftp2; SP-C]

PSPC_MOUSE

E Coli

Mus musculus (Mouse)

193

The sequence of the target protein is listed below. FSIGSTG IVVYDYQRLL TAYKPAPGTY CYIMKMAPES IPSLEAFARK LQNFRAKPST PTSKLGQEEG HDTGSESDSS GRDLAFLGLA VSTLCGELPL YYI

> 95%

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). (May be suitable for use in other assays to be determined by the end user.)!!Reconstitute Reconstitute in sterile ddH2O.

SDS-Page

Residues: Phe94~Ile193. Tags: N-terminal His-Tag. Accession: P21841. Subcellular Location: Secreted, extracellular space, surface film. Endotoxin Level: <1.0EU per 1ug (determined by the LAL method).

Predicted isoelectric point: 6.4. Predicted Molecular Mass: 12.4kDa

131426

P21841.1

P21841

12.4kDa

SFTPC: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. Defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (SMDP2); also called pulmonary alveolar proteinosis due to surfactant protein C deficiency. A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPC are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called hyaline membranes . 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid-binding. Cellular Component: multivesicular body; extracellular space; cytoplasm; extracellular region. Molecular Function: protein homodimerization activity. Biological Process: protein homooligomerization

0.01 mg

145 USD

0.05 mg

275

0.1 mg

430

0.2 mg

525

0.5 mg

1015

1 mg

1515