protein

Recombinant Complement 1 Inhibitor (C1INH)

MBS2011266

0.01 mg

150 USD

Recombinant Protein

Recombinant Complement 1 Inhibitor (C1INH)

[Complement 1 Inhibitor (C1INH)]

[plasma protease C1 inhibitor; Plasma protease C1 inhibitor; plasma protease C1 inhibitor; C1 Inh; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine (or cysteine) proteinase inhibitor, clade G, member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) peptidase inhibitor, clade G, member 1; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1]

[C1INH]

[Serping1; Serping1; C1nh; C1INH; C1nh; C1 Inh; C1Inh]

IC1_MOUSE

E. coli

VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL SAKWKITFEP KKMMAPFFYK NSMIKVPMMS S

> 97%

PBS, pH7.4, containing 0.01% SKL.

Original Concentration: 200ug/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Organism: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Val211~Ser331. tAGS: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder. Predicted isoelectric point: 10.0. Usage: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

163914390

NP_033906.2

NM_009776.3

P97290

Predicted Molecular Mass: 14.7kDa. Accurate Molecular Mass: 15kDa as determined by SDS-PAGE reducing conditions.

Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (925989); Hemostasis Pathway (925961); Intrinsic Pathway (925991); Pertussis Pathway (218112); Pertussis Pathway (218099); Platelet Activation, Signaling And Aggregation Pathway (925971); Platelet Degranulation Pathway (925988)

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; extracellular region. Molecular Function: complement binding; serine-type endopeptidase inhibitor activity; protease inhibitor activity. Biological Process: negative regulation of complement activation, lectin pathway; fibrinolysis; immune system process; negative regulation of complement activation; hemostasis; regulation of blood coagulation; negative regulation of peptidase activity; innate immune response; blood coagulation; complement activation, classical pathway

0.01 mg

150 USD

0.05 mg

290

0.1 mg

455

0.2 mg

560

0.5 mg

1080

1 mg

1610