Recombinant Interleukin 31 Receptor A (IL31RA) | MyBioSource MBS2011131 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Interleukin 31 Receptor A (IL31RA)

catalog :

MBS2011131

quantity :

0.01 mg

price :

145 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2011131

products type :

Recombinant Protein

products full name :

Recombinant Interleukin 31 Receptor A (IL31RA)

products short name :

[Interleukin 31 Receptor A (IL31RA)]

other names :

[interleukin-31 receptor subunit alpha isoform 2; Interleukin-31 receptor subunit alpha; interleukin-31 receptor subunit alpha; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3; interleukin 31 receptor A; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17]

products gene name :

[IL31RA]

other gene names :

[IL31RA; IL31RA; CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; CRL3; GPL; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; hGLM-R]

uniprot entry name :

IL31R_HUMAN

host :

E Coli

purity :

> 90%

concentration :

Original Concentration: 200 Ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Val205~Gly456. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose. Predicted isoelectric point: 6.0. Predicted Molecular Mass: 32.6kDa. Accurate Molecular Mass: 32kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

336391156

ncbi acc num :

NP_001229565.1

ncbi gb acc num :

NM_001242636.1

uniprot acc num :

Q8NI17

ncbi summary :

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

uniprot summary :

IL31RA: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2). PLCA2 is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 12 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: plasma membrane; integral to membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; cytokine binding; transcription coactivator activity; protein kinase binding. Biological Process: macrophage differentiation; monocyte differentiation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; defense response; JAK-STAT cascade; positive regulation of tyrosine phosphorylation of Stat3 protein; homeostatic process; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of cell proliferation; negative regulation of macrophage activation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis. Disease: Amyloidosis, Primary Localized Cutaneous, 2

size1 :

0.01 mg

price1 :

145 USD

size2 :

0.05 mg

price2 :

285

size3 :

0.1 mg

price3 :

445

size4 :

0.2 mg

price4 :

545

size5 :

0.5 mg

price5 :

1055

size6 :

1 mg

price6 :

1575

more info or order :

MyBioSource product webpage