Recombinant Caveolin 1 (CAV1) | MyBioSource MBS2011039 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Caveolin 1 (CAV1)

catalog :

MBS2011039

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2011039

products type :

Recombinant Protein

products full name :

Recombinant Caveolin 1 (CAV1)

products short name :

Caveolin 1 (CAV1)

other names :

caveolin-1 isoform 2; Caveolin-1; caveolin-1; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; caveolin 1, caveolae protein

products gene name :

CAV1

other gene names :

Cav1; Cav1; Cav; Cav-1; Cav

uniprot entry name :

CAV1_MOUSE

host :

E Coli

sequence length :

147

sequence :

The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLS

purity :

> 95%

form :

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Met1~Ser104 (Accession # P49817) with two N-terminal Tags, His-tag and GST-tag. Predicted isoelectric point: 5.8

other info2 :

Endotoxin Level: <1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

340139110

ncbi acc num :

NP_001229993.1

ncbi gb acc num :

NM_001243064.1

uniprot acc num :

P49817

ncbi mol weight :

43.9kDa

ncbi pathways :

Androgen Receptor Signaling Pathway (198319); Bacterial Invasion Of Epithelial Cells Pathway (149817); Bacterial Invasion Of Epithelial Cells Pathway (148661); Basigin Interactions Pathway (925996); Cell Surface Interactions At The Vascular Wall Pathway (925994); EGFR1 Signaling Pathway (198278); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Focal Adhesion Pathway (198353); Focal Adhesion Pathway (83264)

uniprot summary :

Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation. Protein type: Adaptor/scaffold; Nuclear receptor co-regulator; Motility/polarity/chemotaxis. Cellular Component: peroxisomal membrane; Golgi apparatus; cell surface; mitochondrion; basolateral plasma membrane; integral to plasma membrane; integral to membrane; lipid particle; cytosol; lipid raft; acrosomal membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; intracellular; cytoplasmic vesicle; endosome; focal adhesion; protein complex; endoplasmic reticulum; cell; caveola; cell cortex; cilium; Golgi membrane; plasma membrane. Molecular Function: protein binding, bridging; identical protein binding; protease activator activity; protein kinase binding; SNARE binding; protein binding; enzyme binding; syntaxin binding; protein heterodimerization activity; protein complex scaffold; nitric-oxide synthase binding; structural molecule activity; kinase binding; receptor binding. Biological Process: mammary gland involution; negative regulation of MAP kinase activity; negative regulation of epithelial cell differentiation; negative regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of endocytosis; nitric oxide homeostasis; negative regulation of BMP signaling pathway; calcium ion homeostasis; sequestering of lipid; protein localization; regulation of the force of heart contraction by chemical signal; regulation of fatty acid metabolic process; negative regulation of protein binding; regulation of the force of heart contraction; inactivation of MAPK activity; microtubule polymerization; maintenance of cellular protein localization; regulation of smooth muscle contraction; skeletal muscle development; cytosolic calcium ion homeostasis; negative regulation of nitric-oxide synthase activity; positive regulation of signal transduction; endocytosis; protein oligomerization; membrane depolarization; negative regulation of neuron differentiation; cholesterol homeostasis; response to mechanical stimulus; response to estrogen stimulus; negative regulation of endothelial cell proliferation; T cell costimulation; negative regulation of protein ubiquitination; positive regulation of endothelial cell proliferation; response to progesterone stimulus; response to calcium ion; negative regulation of JAK-STAT cascade; lactation; wound healing; negative regulation of smooth muscle cell proliferation; positive regulation of microtubule polymerization; negative regulation of peptidyl-serine phosphorylation; negative regulation of pinocytosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; mammary gland development; calcium ion transport; negative regulation of cytokine and chemokine mediated signaling pathway; angiogenesis; vasculogenesis; protein homooligomerization; vasoconstriction; negative regulation of MAPKKK cascade; negative regulation of nitric oxide biosynthetic process; MAPKKK cascade; cholesterol efflux; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; regulation of peptidase activity; negative regulation of signal transduction; cellular calcium ion homeostasis; triacylglycerol metabolic process; regulation of blood coagulation; response to hypoxia; positive regulation of vasoconstriction

size1 :

0.01 mg

price1 :

205 USD

size2 :

0.05 mg

price2 :

460

size3 :

0.1 mg

price3 :

715

more info or order :

MyBioSource product webpage