protein

Recombinant Cathepsin C (CTSC)

MBS2011032

0.01 mg

150 USD

Recombinant Protein

Recombinant Cathepsin C (CTSC)

[Cathepsin C (CTSC)]

[dipeptidyl peptidase 1 preproprotein; Dipeptidyl peptidase 1; dipeptidyl peptidase 1; DPP-I; cathepsin J; dipeptidylpeptidase 1; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; cathepsin C; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferaseCleaved into the following 3 chains:Dipeptidyl peptidase 1 exclusion domain chain; Alternative name(s):; Dipeptidyl peptidase I exclusion domain chainDipeptidyl peptidase 1 heavy chain; Alternative name(s):; Dipeptidyl peptidase I heavy chainDipeptidyl peptidase 1 light chain; Alternative name(s):; Dipeptidyl peptidase I light chain]

[CTSC]

[Ctsc; Ctsc; DPP1; DPPI; AI047818; DPP-I; DPPI]

CATC_MOUSE

E Coli

PESWDWRNVQ GVNYVSPVRN QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE SIAVAAIPIP KL

> 95%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Original Concentration: 150ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Organism: Mus musculus (Mouse). Expression System: Prokaryotic expression. Residues: Pro231~Leu462. Tags: N-terminal His Tag. Subcellular Location: Lysosome. Traits: Freeze-dried powder. Predicted Isoelectric Point: 5.9. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

160707990

NP_034112.3

NM_009982.4

P97821

Predicted Molecular Mass: 27.2kDa. Accurate Molecular Mass: 26kDa as determined by SDS-PAGE reducing conditions.

Lysosome Pathway (99272); Lysosome Pathway (96865)

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]

CTSC: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Defects in CTSC are a cause of Papillon-Lefevre syndrome (PLS); also known as keratosis palmoplantaris with periodontopathia. PLS is an autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Defects in CTSC are a cause of Haim-Munk syndrome (HMS); also known as keratosis palmoplantaris with periodontopathia and onychogryposis or Cochin Jewish disorder. HMS is an autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Defects in CTSC are a cause of aggressive periodontititis type 1 (AP1); also known as juvenile periodontitis (JPD) and prepubertal periodontitis (PPP). AP1 is characterized by severe and protracted gingival infections, leading to tooth loss. AP1 inheritance is autosomal dominant. Belongs to the peptidase C1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Endoplasmic reticulum; Protease; EC 3.4.14.1. Cellular Component: Golgi apparatus; extracellular space; membrane; endoplasmic reticulum; lysosome. Molecular Function: peptidase activity; identical protein binding; protein self-association; hydrolase activity; chaperone binding; serine-type endopeptidase activity; apoptotic protease activator activity; chloride ion binding; phosphatase binding; cysteine-type peptidase activity. Biological Process: response to organic substance; apoptosis; proteolysis; T cell mediated cytotoxicity

0.01 mg

150 USD

0.05 mg

290

0.1 mg

455

0.2 mg

560

0.5 mg

1080

1 mg

1610