catalog number :
MBS2010984
products type :
Recombinant Protein
products full name :
Recombinant Carcinoembryonic Antigen (CEA)
products short name :
[Carcinoembryonic Antigen (CEA)]
other names :
[carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein; Carcinoembryonic antigen-related cell adhesion molecule 5; carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100; carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100]
products gene name :
[CEA]
other gene names :
[CEACAM5; CEACAM5; CEA; CD66e; CEA; CEA]
uniprot entry name :
CEAM5_HUMAN
form :
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
concentration :
Original Concentration: 200 ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
Sequence Information
image2 heading :
SDS-Page
image3 heading :
Testing Data
other info1 :
Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Ala566~Gly698. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 5.9. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_004354.2
ncbi gb acc num :
NM_004363.3
ncbi mol weight :
Predicted: 15.0kDa. Accurate: 16/25kDa as determined by SDS-PAGE reducing conditions.
ncbi summary :
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
uniprot summary :
CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. Protein type: Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 19q13.1-q13.2. Cellular Component: basolateral plasma membrane; integral to plasma membrane. Molecular Function: identical protein binding; protein homodimerization activity. Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis