catalog number :
MBS2010947
products type :
Recombinant Protein
products full name :
Recombinant Anti-Mullerian Hormone (AMH)
products short name :
Anti-Mullerian Hormone (AMH)
other names :
muellerian-inhibiting factor; Muellerian-inhibiting factor; muellerian-inhibiting factor; anti-Muellerian hormone; Mullerian inhibiting factor; Mullerian inhibiting substance; muellerian-inhibiting substance; anti-Mullerian hormone; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance
other gene names :
AMH; AMH; MIF; MIS; MIF; AMH; MIS
uniprot entry name :
MIS_HUMAN
form :
PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
storage stability :
Storage : Avoid repeated freeze/thaw cycles.Store at 2-8 degee C for one month.Aliquot and store at -80 degree C for 12 months. Stability Test : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.)
other info1 :
Source: Prokaryotic expression. Residues: Ala453~Arg560. Tags: N-terminal His-Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder.
other info2 :
Predicted isoelectric point: 7.7. Predicted Molecular Mass: 12.8kDa. Accurate Molecular Mass: 14kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex
ncbi acc num :
NP_000470.2
ncbi gb acc num :
NM_000479.3
ncbi pathways :
ALK2 Signaling Events Pathway (137983); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)
ncbi summary :
Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2008]
uniprot summary :
AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: growth factor activity; hormone activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: sex determination; response to drug; Mullerian duct regression; cell-cell signaling; gonadal mesoderm development; preantral ovarian follicle growth; sex differentiation; response to organic cyclic substance; urogenital system development; activation of NF-kappaB transcription factor; aging. Disease: Persistent Mullerian Duct Syndrome, Types I And Ii