Recombinant RAR Related Orphan Receptor Gamma (RORg) | MyBioSource MBS2010934 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant RAR Related Orphan Receptor Gamma (RORg)

catalog :

MBS2010934

quantity :

0.01 mg

price :

185 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2010934

products type :

Recombinant Protein

products full name :

Recombinant RAR Related Orphan Receptor Gamma (RORg)

products short name :

RAR Related Orphan Receptor Gamma (RORg)

other names :

nuclear receptor ROR-gamma isoform b; Nuclear receptor ROR-gamma; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; Retinoid-related orphan receptor-gamma

products gene name :

RORg

other gene names :

RORC; RORC; TOR; RORG; RZRG; NR1F3; RZR-GAMMA; NR1F3; RORG; RZRG

uniprot entry name :

RORG_HUMAN

host :

E Coli

sequence length :

497

sequence :

The target protein sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-EGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ S

purity :

> 95%

form :

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

other info1 :

Organism: Homo sapiens (Human). Expression System: Prokaryotic expression. Residues: Glu212~Ser461 (Accession # P51449) with two N-terminal Tags, His-tag and T7-tag. Predicted isoelectric point: 6.6

other info2 :

Endotoxin Level: Less than 1.0EU per 1ug (determined by the LAL method). Reconstitution: Reconstitute in ddH2O

products description :

About the Marker: Effective Size Range: 10kDa to 70kDa. Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa. Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy. Ready-to-use: No need to heat, dilute or add reducing agents before use.

ncbi gi num :

48255918

ncbi acc num :

NP_001001523.1

ncbi gb acc num :

NM_001001523.1

uniprot acc num :

P51449

ncbi mol weight :

32.6kDa

ncbi pathways :

Circadian Rhythm Pathway (83084); Circadian Rhythm Pathway (495); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848)

ncbi summary :

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: nucleoplasm; nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; oxysterol binding; steroid hormone receptor activity; transcription factor activity. Biological Process: Peyer s patch development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; regulation of fat cell differentiation; T-helper cell differentiation; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of circadian rhythm; protein amino acid phosphorylation; lymph node development; regulation of gamma-delta T cell differentiation; xenobiotic metabolic process; regulation of steroid metabolic process; gene expression; steroid hormone mediated signaling; circadian regulation of gene expression

size1 :

0.01 mg

price1 :

185 USD

size2 :

0.05 mg

price2 :

390

size3 :

0.1 mg

price3 :

600

more info or order :

MyBioSource product webpage